ID   PYYV_VARER              Reviewed;          99 AA.
AC   E2E4L2;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Goannatyrotoxin-Vere1;
DE   AltName: Full=Venom peptide YY-like;
DE   Flags: Precursor;
OS   Varanus eremius (Pygmy desert monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=62040;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 29-64, AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=20631207; DOI=10.1074/mcp.m110.001370;
RA   Fry B.G., Winter K., Norman J.A., Roelants K., Nabuurs R.J., van Osch M.J.,
RA   Teeuwisse W.M., van der Weerd L., McNaughtan J.E., Kwok H.F., Scheib H.,
RA   Greisman L., Kochva E., Miller L.J., Gao F., Karas J., Scanlon D., Lin F.,
RA   Kuruppu S., Shaw C., Wong L., Hodgson W.C.;
RT   "Functional and structural diversification of the Anguimorpha lizard venom
RT   system.";
RL   Mol. Cell. Proteomics 9:2369-2390(2010).
CC   -!- FUNCTION: Shows a potent unique triphasic action, rapid biphasic
CC       hypertension followed by prolonged hypotension.
CC       {ECO:0000269|PubMed:20631207}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; GU441529; ADK39293.1; -; mRNA.
DR   AlphaFoldDB; E2E4L2; -.
DR   TCDB; 8.A.106.2.2; the caltrin/peptide yy (caltrin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hypotensive agent;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..64
FT                   /note="Goannatyrotoxin-Vere1"
FT                   /id="PRO_0000412879"
FT   PROPEP          68..99
FT                   /note="C-terminal extension"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000412880"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11283 MW;  1CC07D42977EE7CA CRC64;
     MIASMKPWPL VMVAALCILF CLGTLVDAYP TKPESPGPDA TPEELAEYMT KIRQYINLVT
     RQRYGKRSSP ETLMSELIFG ENSNSDHSSR SRFDDSYMW