PYY_BOVIN
ID PYY_BOVIN Reviewed; 97 AA.
AC P51694; Q3T155;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Peptide YY;
DE Short=PYY;
DE AltName: Full=Peptide tyrosine tyrosine;
DE Flags: Precursor;
GN Name=PYY;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7831336; DOI=10.1073/pnas.92.2.594;
RA Herzog H., Hort Y., Schneider R., Shine J.;
RT "Seminalplasmin: recent evolution of another member of the neuropeptide Y
RT gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:594-598(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has
CC a vasoconstrictory action and inhibitis jejunal and colonic mobility.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L37369; AAC37326.1; -; Genomic_DNA.
DR EMBL; BC102123; AAI02124.1; -; mRNA.
DR PIR; A55914; A55914.
DR RefSeq; NP_001035677.1; NM_001040587.2.
DR AlphaFoldDB; P51694; -.
DR STRING; 9913.ENSBTAP00000055348; -.
DR PaxDb; P51694; -.
DR Ensembl; ENSBTAT00000062944; ENSBTAP00000055348; ENSBTAG00000046022.
DR GeneID; 615800; -.
DR KEGG; bta:615800; -.
DR CTD; 5697; -.
DR VEuPathDB; HostDB:ENSBTAG00000046022; -.
DR eggNOG; ENOG502S267; Eukaryota.
DR GeneTree; ENSGT00940000160643; -.
DR HOGENOM; CLU_162379_1_0_1; -.
DR InParanoid; P51694; -.
DR OMA; HAYPAKP; -.
DR OrthoDB; 1542445at2759; -.
DR TreeFam; TF332778; -.
DR Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000046022; Expressed in ascending colon and 78 other tissues.
DR ExpressionAtlas; P51694; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Hormone; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000250"
FT PEPTIDE 29..64
FT /note="Peptide YY"
FT /id="PRO_0000025380"
FT PROPEP 68..97
FT /id="PRO_0000025381"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P68005"
FT MOD_RES 64
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 97 AA; 11092 MW; B3A7B6A768BB3AE0 CRC64;
MMSGRRSWPA MATVLLTLLV CLGELVDAYP AKPQAPGEHA SPDELNRYYT SLRHYLNLVT
RQRFGKRDFS EALLSILLFP DREDPPVKSR PEGAYLW
