ID   PYY_CANLF               Reviewed;          36 AA.
AC   P68004; P01305;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Peptide YY {ECO:0000303|PubMed:2342986};
DE            Short=PYY {ECO:0000303|PubMed:2342986};
DE   AltName: Full=Peptide tyrosine tyrosine;
DE   Contains:
DE     RecName: Full=Peptide YY(3-36) {ECO:0000303|PubMed:2342986};
GN   Name=PYY;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC   TISSUE=Colon mucosa;
RX   PubMed=2342986; DOI=10.1016/0196-9781(90)90118-o;
RA   Eysselein V.E., Eberlein G.A., Grandt D., Schaeffer M., Zehres B., Behn U.,
RA   Schaefer D., Goebell H., Davis M., Lee T.D., Shively J.E., Meyer H.E.,
RA   Reeve J.R. Jr.;
RT   "Structural characterization of canine PYY.";
RL   Peptides 11:111-116(1990).
CC   -!- FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has
CC       a vasoconstrictory action and inhibitis jejunal and colonic mobility.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: The peptide YY form is cleaved at Pro-2 by the prolyl
CC       endopeptidase FAP (seprase) activity (in vitro) to generate peptide
CC       YY(3-36). {ECO:0000250|UniProtKB:P10082}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A60416; A60416.
DR   AlphaFoldDB; P68004; -.
DR   BMRB; P68004; -.
DR   SMR; P68004; -.
DR   STRING; 9612.ENSCAFP00000021232; -.
DR   PaxDb; P68004; -.
DR   eggNOG; ENOG502S267; Eukaryota.
DR   InParanoid; P68004; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; ISS:AgBase.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Phosphoprotein;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Peptide YY"
FT                   /id="PRO_0000025382"
FT   PEPTIDE         3..36
FT                   /note="Peptide YY(3-36)"
FT                   /id="PRO_0000025383"
FT   SITE            2..3
FT                   /note="Cleavage; by FAP"
FT                   /evidence="ECO:0000250|UniProtKB:P10082"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P68005"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:2342986"
SQ   SEQUENCE   36 AA;  4242 MW;  02CD6B8C586DCC8D CRC64;
     YPAKPEAPGE DASPEELSRY YASLRHYLNL VTRQRY