PYY_LAMFL
ID PYY_LAMFL Reviewed; 93 AA.
AC P48098;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Peptide YY-like;
DE Short=PYY;
DE Flags: Precursor;
GN Name=pyy;
OS Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX NCBI_TaxID=7748;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain, and Spinal cord;
RX PubMed=8028041; DOI=10.1002/jnr.490370510;
RA Soederberg C., Pieribone V.A., Dahlstrand J., Brodin L., Larhammar D.;
RT "Neuropeptide role of both peptide YY and neuropeptide Y in vertebrates
RT suggested by abundant expression of their mRNAs in a cyclostome brain.";
RL J. Neurosci. Res. 37:633-640(1994).
CC -!- FUNCTION: Gastrointestinal hormone and neuropeptide.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Gut and medial reticulospinal neuron system in the
CC brainstem.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR EMBL; L22868; AAA21353.1; -; mRNA.
DR PIR; I50809; I50809.
DR AlphaFoldDB; P48098; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PEPTIDE 28..63
FT /note="Peptide YY-like"
FT /id="PRO_0000025401"
FT PROPEP 65..93
FT /note="C-terminal extension"
FT /id="PRO_0000025402"
FT MOD_RES 63
FT /note="Tyrosine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 93 AA; 10551 MW; 53B9B4C51B4BF329 CRC64;
MVSPRVRLAA LALSVCAILC LGMHASAFPP KPDNPGDNAS PEQMARYKAA VRHYINLITR
QRYGKRALTP ENWIYRDPAE ERVTYGLDDY AMW