ID   PYY_RABIT               Reviewed;          36 AA.
AC   Q9TR93; Q9TR92;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Peptide YY {ECO:0000303|PubMed:7984499};
DE            Short=PYY {ECO:0000303|PubMed:7984499};
DE   AltName: Full=PYY-I {ECO:0000303|PubMed:7984499};
DE   AltName: Full=Peptide tyrosine tyrosine;
DE   Contains:
DE     RecName: Full=Peptide YY(3-36) {ECO:0000303|PubMed:7984499};
DE     AltName: Full=PYY-II {ECO:0000303|PubMed:7984499};
GN   Name=PYY;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC   TISSUE=Intestinal mucosa;
RX   PubMed=7984499; DOI=10.1016/0196-9781(94)90035-3;
RA   Grandt D., Schimiczek M., Struk K., Shively J., Eysselein V.E., Goebell H.,
RA   Reeve J.R. Jr.;
RT   "Characterization of two forms of peptide YY, PYY(1-36) and PYY(3-36), in
RT   the rabbit.";
RL   Peptides 15:815-820(1994).
CC   -!- FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has
CC       a vasoconstrictory action and inhibitis jejunal and colonic mobility.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The peptide YY form is cleaved at Pro-2 by the prolyl
CC       endopeptidase FAP (seprase) activity (in vitro) to generate peptide
CC       YY(3-36). {ECO:0000250|UniProtKB:P10082}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9TR93; -.
DR   BMRB; Q9TR93; -.
DR   SMR; Q9TR93; -.
DR   STRING; 9986.ENSOCUP00000011243; -.
DR   eggNOG; ENOG502S267; Eukaryota.
DR   InParanoid; Q9TR93; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Phosphoprotein;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Peptide YY"
FT                   /id="PRO_0000025389"
FT   PEPTIDE         3..36
FT                   /note="Peptide YY(3-36)"
FT                   /id="PRO_0000025390"
FT   SITE            2..3
FT                   /note="Cleavage; by FAP"
FT                   /evidence="ECO:0000250|UniProtKB:P10082"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P68005"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:7984499"
SQ   SEQUENCE   36 AA;  4285 MW;  02D499C8086DCC8D CRC64;
     YPSKPEAPGE DASPEELNRY YASLRHYLNL VTRQRY