ID   PY_DICLA                Reviewed;          97 AA.
AC   Q9PT98;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Peptide Y;
DE   Flags: Precursor;
OS   Dicentrarchus labrax (European seabass) (Morone labrax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Dicentrarchus.
OX   NCBI_TaxID=13489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9629200; DOI=10.1111/j.1749-6632.1998.tb10846.x;
RA   Cerda-Reverter J.M., Martinez-Rodriguez G., Zanuy S., Carrillo M.,
RA   Larhammar D.;
RT   "Cloning of neuropeptide Y, peptide YY, and peptide Y from sea bass
RT   (Dicentrarchus labrax), a marine teleost.";
RL   Ann. N. Y. Acad. Sci. 839:493-495(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AJ005380; CAB64934.1; -; mRNA.
DR   AlphaFoldDB; Q9PT98; -.
DR   SMR; Q9PT98; -.
DR   Proteomes; UP000694389; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         29..64
FT                   /note="Peptide Y"
FT                   /id="PRO_0000025397"
FT   PROPEP          68..97
FT                   /note="C-terminal extension"
FT                   /id="PRO_0000025398"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  10921 MW;  EB95943A562DD9C4 CRC64;
     MANMLRSWMM LAALAVCLLV CLSSFADAYP PKPESPGSNA SPEDWAKYHA AVRHYVNLIT
     RQRYGKRSTP EQAVAWLLFG ADSSQDAEPR LDYSDQW