PZNA_BACPA
ID PZNA_BACPA Reviewed; 41 AA.
AC B3A0N7; W1JF39;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Plantazolicin {ECO:0000303|PubMed:21950656};
DE Short=PZN {ECO:0000303|PubMed:21950656};
DE Flags: Precursor;
GN Name=pznA {ECO:0000250|UniProtKB:D3VML5};
OS Bacillus pumilus (strain ATCC 7061 / DSM 27 / CCUG 26015 / JCM 2508 / NBRC
OS 12092 / NCIMB 9369 / NCTC 10337 / NRRL NRS-272 / CCM 2144).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=536229;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7061 / DSM 27 / CCUG 26015 / JCM 2508 / NBRC 12092 / NCIMB 9369
RC / NCTC 10337 / NRRL NRS-272 / CCM 2144 {ECO:0000305};
RA Dodson R.J., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C.,
RA Bruce D., Sutton G., Venkateswaran K., Fox G., Laduc M.T., Brettin T.S.;
RT "Genome sequence of Bacillus pumilis ATCC 7061.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP IDENTIFICATION, AND MASS SPECTROMETRY.
RC STRAIN=ATCC 7061 / DSM 27 / CCUG 26015 / JCM 2508 / NBRC 12092 / NCIMB 9369
RC / NCTC 10337 / NRRL NRS-272 / CCM 2144 {ECO:0000269|PubMed:21950656};
RX PubMed=21950656; DOI=10.1021/cb200339d;
RA Molohon K.J., Melby J.O., Lee J., Evans B.S., Dunbar K.L., Bumpus S.B.,
RA Kelleher N.L., Mitchell D.A.;
RT "Structure determination and interception of biosynthetic intermediates for
RT the plantazolicin class of highly discriminating antibiotics.";
RL ACS Chem. Biol. 6:1307-1313(2011).
CC -!- FUNCTION: Peptide antibiotic inhibiting growth of Gram-positive
CC bacteria. The mode of action appears to be disruption of cell walls and
CC lysis of cells (By similarity). {ECO:0000250|UniProtKB:D3VML5}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000250|UniProtKB:D3VML5}.
CC -!- PTM: Maturation of thiazole and oxazole containing antibiotics involves
CC the enzymatic condensation of a Cys, Ser or Thr with the alpha-carbonyl
CC of the preceding amino acid to form a thioether or ether bond, then
CC dehydration to form a double bond with the alpha-amino nitrogen.
CC Thiazoline or oxazoline ring are dehydrogenated to form thiazole or
CC oxazole rings. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1336.48; Method=Electrospray;
CC Note=Plantazolicin A.; Evidence={ECO:0000269|PubMed:21950656};
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DR EMBL; ABRX01000001; EHD25717.1; -; Genomic_DNA.
DR AlphaFoldDB; B3A0N7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR026474; Plantazolicin.
DR TIGRFAMs; TIGR04218; TOMM_plantaz; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Bacteriocin; Cell wall; Methylation; Secreted;
KW Thioether bond.
FT PROPEP 1..27
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT /id="PRO_0000415153"
FT PEPTIDE 28..41
FT /note="Plantazolicin"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT /id="PRO_0000415154"
FT MOD_RES 28
FT /note="N2,N2-dimethylarginine; in form plantazolicin A"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 28..29
FT /note="Thiazole-4-carboxylic acid (Arg-Cys)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 29..30
FT /note="5-methyloxazole-4-carboxylic acid (Cys-Thr)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 30..31
FT /note="Thiazole-4-carboxylic acid (Thr-Cys)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 31..32
FT /note="5-methyloxazole-4-carboxylic acid (Cys-Thr)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 32..33
FT /note="5-methyloxazole-4-carboxylic acid (Thr-Thr)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 35..36
FT /note="Oxazole-4-carboxylic acid (Ile-Ser)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 36..37
FT /note="Oxazole-4-carboxylic acid (Ser-Ser)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 37..38
FT /note="Oxazole-4-carboxylic acid (Ser-Ser)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 38..39
FT /note="Oxazole-4-carboxylic acid (Ser-Ser)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
FT CROSSLNK 39..40
FT /note="5-methyloxazoline-4-carboxylic acid (Ser-Thr)"
FT /evidence="ECO:0000250|UniProtKB:D3VML5"
SQ SEQUENCE 41 AA; 4368 MW; FDDFC0F75D46E3DC CRC64;
MTKITIPTAL SAKVHGEGQH LFEPMAARCT CTTIISSSST F
