P_PIG
ID P_PIG Reviewed; 845 AA.
AC Q8MIQ9;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 3.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=P protein;
DE AltName: Full=Melanocyte-specific transporter protein;
DE AltName: Full=Pink-eyed dilution protein homolog;
GN Name=Oca2; Synonyms=P;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT HIS-573.
RX PubMed=12354157; DOI=10.1046/j.1365-2052.2002.00896_11.x;
RA Fernandez A., Castellanos C., Rodriguez C., Noguera J.L., Sanchez A.,
RA Ovilo C.;
RT "Physical and linkage mapping of the porcine pink-eye dilution gene
RT (OCA2).";
RL Anim. Genet. 33:392-394(2002).
RN [2]
RP SEQUENCE REVISION TO 634.
RA Fernandez A., Castellanos C., Rodriguez M., Noguera J.L., Sanchez A.,
RA Silio L.L., Ovilo C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could be involved in the transport of tyrosine, the precursor
CC to melanin synthesis, within the melanocyte. Regulates the pH of
CC melanosome and the melanosome maturation. One of the components of the
CC mammalian pigmentary system. Seems to regulate the postranslational
CC processing of tyrosinase, which catalyzes the limiting reaction in
CC melanin synthesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Questioning colour - Issue
CC 54 of January 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/054";
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DR EMBL; AY095536; AAM34404.3; -; mRNA.
DR RefSeq; NP_999259.2; NM_214094.2.
DR AlphaFoldDB; Q8MIQ9; -.
DR STRING; 9823.ENSSSCP00000016801; -.
DR PaxDb; Q8MIQ9; -.
DR PRIDE; Q8MIQ9; -.
DR GeneID; 397171; -.
DR KEGG; ssc:397171; -.
DR CTD; 4948; -.
DR eggNOG; KOG2639; Eukaryota.
DR InParanoid; Q8MIQ9; -.
DR OrthoDB; 495573at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0033162; C:melanosome membrane; IBA:GO_Central.
DR GO; GO:0042438; P:melanin biosynthetic process; IBA:GO_Central.
DR GO; GO:0030318; P:melanocyte differentiation; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR Pfam; PF03600; CitMHS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..845
FT /note="P protein"
FT /id="PRO_0000172511"
FT TOPO_DOM 1..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 415..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..513
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 535..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 651
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 673..687
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 709..730
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 731..751
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 752..773
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 774..794
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 795..820
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 821..841
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 842..845
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 573
FT /note="R -> H"
FT /evidence="ECO:0000269|PubMed:12354157"
SQ SEQUENCE 845 AA; 93185 MW; D62D6D0011629A7D CRC64;
MRLENREGRP TSGVLEMELP QASAPSRAGL GSLGLVGLDS SNHRPQQGGS KAGSRGPYLS
GAAGQSCWVP MDQDFGPFLT ERRSHCPFPK HFSSRSKDPC FTENTPLLGS FSQEEGSRCI
PVYRPEFITA DEPWENSSAE WEGGALLSTE LAVSSGSAST EKGELLDSAH IRCHLSKLRC
CVQWLKVSGL FVFVVLCSIL FSLYPDQGKF WQLLAVSPLE SYSVNLSSHA DSMLLQVDLA
GALVASGPSH LGKEEHVAVE VTQANAPGSR RRRPQQVTHN WTIFLNPSGG EHTVMSRTFE
VLSREPVSIN IRASLQQTQI VPLLMAHQYL RASIEAQVTI AAVILAGVYV LIIFEIVHRT
LAAMLGSLAA LAALAVIGDR PTLTQVVEWI DFETLALLFG MMILVAIFSE TGFFDYCAVK
AYQLSRGRVW AMIIMLCLIA AVLSAFLDNV TTALLFTPVT IRLCEVLNLD PRQVLIAEVI
FTNIGGAATA IGDPPNVIIV SNQELRKMGL DFAGFTAHMF AGICFVLLFS FPLLRLLYWN
RKLYNKEPSE IVELKHEIHV WRLTAQRISP ASREETAVRG LLLEKVLSLE RLLARRLHSF
HRQISQEDKN WETNIQELQK KHRISDRTLL TKCVTVLGLV IFMFFLNSFV PGVHLDLGWI
AILGAIWLLI LADIHDFEII LHRVEWATLL FFAALFILME ALAHLHLIEY VGEQTALLIK
MVPEDQRLAA AIIVVVWVSA IASSLIDNIP FTATMIPVLL NLSRDPEISL PAPPLMYALA
LGACLGGNGT LIGASANVVC AGIAEQHGYG FSFMEFFRLG FPMMVVSCMV GMCYLLVAHV
VMGWN
