ID   Q2OA_COMTE              Reviewed;          11 AA.
AC   P80464;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   11-DEC-2019, entry version 45.
DE   RecName: Full=Quinoline 2-oxidoreductase alpha chain;
DE            EC=1.3.99.17 {ECO:0000269|PubMed:7556204};
DE   Flags: Fragment;
OS   Comamonas testosteroni (Pseudomonas testosteroni).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=285;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, AND COFACTOR.
RC   STRAIN=63;
RX   PubMed=7556204; DOI=10.1111/j.1432-1033.1995.tb20841.x;
RA   Schach S., Tshisuaka B., Fetzner S., Lingens F.;
RT   "Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase
RT   from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-
RT   methylquinoline degradation.";
RL   Eur. J. Biochem. 232:536-544(1995).
CC   -!- FUNCTION: Converts (3-methyl-)-quinoline to (3-methyl-)2-oxo-1,2-
CC       dihydroquinoline. {ECO:0000269|PubMed:7556204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H2O + quinoline = AH2 + quinolin-2(1H)-one;
CC         Xref=Rhea:RHEA:17749, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17362, ChEBI:CHEBI:17499, ChEBI:CHEBI:18289;
CC         EC=1.3.99.17; Evidence={ECO:0000269|PubMed:7556204};
CC   -!- COFACTOR:
CC       Name=Mo-molybdopterin cytosine dinucleotide; Xref=ChEBI:CHEBI:71308;
CC         Evidence={ECO:0000269|PubMed:7556204};
CC       Note=Binds 1 Mo-molybdopterin cytosine dinucleotide (Mo-MCD) cofactor
CC       per subunit. {ECO:0000269|PubMed:7556204};
CC   -!- PATHWAY: Xenobiotic degradation; quinoline degradation.
CC   -!- SUBUNIT: Heterohexamer of two alpha chains, two beta chains, and two
CC       gamma chains. {ECO:0000305}.
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DR   PIR; S66606; S66606.
DR   UniPathway; UPA00239; -.
DR   GO; GO:0018523; F:quinoline 2-oxidoreductase activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Molybdenum; Oxidoreductase.
FT   CHAIN           1..>11
FT                   /note="Quinoline 2-oxidoreductase alpha chain"
FT                   /id="PRO_0000097129"
FT   NON_TER         11
SQ   SEQUENCE   11 AA;  1213 MW;  869094322B1DC2CA CRC64;
     AKSDVAELKP R