ID   QA1F_NEUCR              Reviewed;         816 AA.
AC   P11638; Q7RV98;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Quinic acid utilization activator;
GN   Name=qa-1f; ORFNames=NCU06028;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=2525625; DOI=10.1016/0022-2836(89)90438-5;
RA   Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J.,
RA   Case M.E., Giles N.H.;
RT   "DNA sequence, organization and regulation of the qa gene cluster of
RT   Neurospora crassa.";
RL   J. Mol. Biol. 207:15-34(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Transcription activation of genes for enzymes and proteins of
CC       quinate metabolism by binding to a 16 base-pair sequence (consensus 5'-
CC       GGRTAARYRYTTAYCC-3') in front of each Qa genes.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X14603; CAA32754.1; -; Genomic_DNA.
DR   EMBL; CM002242; EAA30382.1; -; Genomic_DNA.
DR   PIR; S04256; F31277.
DR   RefSeq; XP_959618.1; XM_954525.2.
DR   AlphaFoldDB; P11638; -.
DR   STRING; 5141.EFNCRP00000005354; -.
DR   EnsemblFungi; EAA30382; EAA30382; NCU06028.
DR   GeneID; 3875756; -.
DR   KEGG; ncr:NCU06028; -.
DR   VEuPathDB; FungiDB:NCU06028; -.
DR   HOGENOM; CLU_007607_0_0_1; -.
DR   InParanoid; P11638; -.
DR   OMA; GVQTGYI; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0019630; P:quinate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Quinate metabolism;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..816
FT                   /note="Quinic acid utilization activator"
FT                   /id="PRO_0000114969"
FT   DNA_BIND        76..103
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          184..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        812
FT                   /note="S -> N (in Ref. 1; CAA32754)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   816 AA;  88920 MW;  8E6FC60B372C4452 CRC64;
     MPPKRKTLNA AAEANAHADG HADGNADGHV ANTAASSNNA RFADLTNIDT PGLGPTTTTL
     LVEPARSKRQ RVSRACDQCR AAREKCDGIQ PACFPCVSQG RSCTYQASPK KRGVQTGYIR
     TLELALAWMF ENVARSEDAL HNLLVRDAGQ GSALLVGKDS PAAERLHARW ATSRVNKSIT
     RLLSGQAAQD PSEDGQSPSE DINVQDAGAK TSDFPHAPHL TFSAPKSSTA ETRTLPGPVR
     PPISANTLEN NLQPDGTGIG KLPPNHWRLL DIYFSYTHSW LPILEKKDMY QALYQYSEQG
     SLLPSANVES GVHAELWSAL ALASFQAAAT AASSATGPAS AAHGHDNAIN PSPADISDTA
     RKLIPLESGP FQVQHCRALL LLCLVSLGRD DWESAWLLVG FAVRVLLVVR TQLPPDDDRP
     RPRMRALLVA CFIVDTIVSM RHNVPAHLKP DDIADLPLPE DGQDQWEPWT PCEGLGGEHT
     MLQMLRNPAY PLSTFNHLYG VTKLVALELL PRIRTSSQNA PLEFRSRLQQ VIGHNSPFSV
     FVLSQDTASA FVPTAYLTRT VYLWAAAFSE PLNEHYSHLL IETLDQYQKR FGTYAIPPLI
     PSLLDSLLAL KKQSHSSERH RRHLEELFPA YSSIWPRGGR HSNTGLQPIR QLELPPTATA
     TASIMPHVME QPLSTSINPV NDRFNGIPNP TPYNSDAALD AITQTNDYGS VNTHGILSTY
     PPPATHLNEA SVALAPGGAP PRPPPPYVDS TTNHPPYHSN LVPMANFGYS TVDYDAMVDD
     LASIEYTDAV DVDPQFMTNL GFVPGCNFSD ISTYEQ