ID   QACC_STASS              Reviewed;         107 AA.
AC   Q55339;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Quaternary ammonium compound-resistance protein QacC;
DE   AltName: Full=Quaternary ammonium determinant C;
GN   Name=qacC {ECO:0000303|PubMed:7592110};
OS   Staphylococcus sp. (strain ST827).
OG   Plasmid pST827.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=126831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=7592110; DOI=10.1111/j.1365-2672.1995.tb00928.x;
RA   Heir E., Sundheim G., Holck A.L.;
RT   "Resistance to quaternary ammonium compounds in Staphylococcus spp.
RT   isolated from the food industry and nucleotide sequence of the resistance
RT   plasmid pST827.";
RL   J. Appl. Bacteriol. 79:149-156(1995).
CC   -!- FUNCTION: Multidrug exporter. Is implicated for the resistance to
CC       bacteriocidal quaternary ammonium compounds.
CC       {ECO:0000269|PubMed:7592110}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14319};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000305}.
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DR   EMBL; Z37964; CAA86016.1; -; Genomic_DNA.
DR   PIR; S51693; S51693.
DR   AlphaFoldDB; Q55339; -.
DR   BMRB; Q55339; -.
DR   SMR; Q55339; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..107
FT                   /note="Quaternary ammonium compound-resistance protein
FT                   QacC"
FT                   /id="PRO_0000108084"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11689 MW;  0B7B4C4B33E2B066 CRC64;
     MPYIYLIISI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM QHLPLNITYA
     TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL NIFGTSH