ID   QACE_ECOLX              Reviewed;         110 AA.
AC   P0AGC9; Q57225;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Quaternary ammonium compound-resistance protein QacE;
DE   AltName: Full=Quaternary ammonium determinant E;
GN   Name=qacE;
OS   Escherichia coli.
OG   Plasmid IncP-beta R751.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8494372; DOI=10.1128/aac.37.4.761;
RA   Paulsen I.T., Littlejohn T.G., Radstroem P., Sundstroem L., Skoeld O.,
RA   Swedberg G., Skurray R.A.;
RT   "The 3' conserved segment of integrons contains a gene associated with
RT   multidrug resistance to antiseptics and disinfectants.";
RL   Antimicrob. Agents Chemother. 37:761-768(1993).
CC   -!- FUNCTION: Multidrug exporter. Is implicated for the resistance to
CC       bacteriocidal quaternary ammonium compounds.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0AGC9; -.
DR   SMR; P0AGC9; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..110
FT                   /note="Quaternary ammonium compound-resistance protein
FT                   QacE"
FT                   /id="PRO_0000108085"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  11472 MW;  94C3CBAFF4C71AC6 CRC64;
     MKGWLFLVIA IVGEVIATSA LKSSEGFTKL APSAVVIIGY GIAFYFLSLV LKSIPVGVAY
     AVWSGLGVVI ITAIAWLLHG QKLDAWGFVG MGLIVSGVVV LNLLSKASAH