ID   QACF_KLEAE              Reviewed;         110 AA.
AC   Q9X2N9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Quaternary ammonium compound-resistance protein QacF;
DE   AltName: Full=Quaternary ammonium determinant F;
GN   Name=qacF;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OG   Plasmid pIP833.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM2688-1; TRANSPOSON=In40;
RX   PubMed=9756755; DOI=10.1128/aac.42.10.2557;
RA   Ploy M.-C., Courvalin P., Lambert T.;
RT   "Characterization of In40 of Enterobacter aerogenes BM2688, a class 1
RT   integron with two new gene cassettes, cmlA2 and qacF.";
RL   Antimicrob. Agents Chemother. 42:2557-2563(1998).
CC   -!- FUNCTION: Multidrug exporter. Is implicated for the resistance to
CC       bacteriocidal quaternary ammonium compounds.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000305}.
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DR   EMBL; AF034958; AAD22143.1; -; Genomic_DNA.
DR   RefSeq; WP_015243636.1; NG_051881.1.
DR   AlphaFoldDB; Q9X2N9; -.
DR   SMR; Q9X2N9; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport; Transposable element.
FT   CHAIN           1..110
FT                   /note="Quaternary ammonium compound-resistance protein
FT                   QacF"
FT                   /id="PRO_0000108087"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  11665 MW;  5E2110C6725E92E0 CRC64;
     MKNWIFLAVS IFGEVIATSA LKSSHGFTRL VPSVVVVAGY GLAFYFLSLA LKSIPVGIAY
     AVWAGLGIVL VAAIAWIFHG QKLDFWAFIG MGLIVSGVAV LNLLSKVSAH