ID   QACH_STASA              Reviewed;         107 AA.
AC   O87868;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Quaternary ammonium compound-resistance protein QacH;
DE   AltName: Full=Quaternary ammonium determinant H;
GN   Name=qacH;
OS   Staphylococcus saprophyticus.
OG   Plasmid pST2H6.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=29385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ST2H6;
RX   PubMed=9631545; DOI=10.1111/j.1574-6968.1998.tb13025.x;
RA   Heir E., Sundheim G., Holck A.L.;
RT   "The Staphylococcus qacH gene product: a new member of the SMR family
RT   encoding multidrug resistance.";
RL   FEMS Microbiol. Lett. 163:49-56(1998).
CC   -!- FUNCTION: Multidrug exporter. Is implicated for the resistance to
CC       bacteriocidal quaternary ammonium compounds.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000305}.
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DR   EMBL; Y16945; CAA76544.1; -; Genomic_DNA.
DR   RefSeq; WP_032489340.1; NG_052082.1.
DR   AlphaFoldDB; O87868; -.
DR   SMR; O87868; -.
DR   PRIDE; O87868; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..107
FT                   /note="Quaternary ammonium compound-resistance protein
FT                   QacH"
FT                   /id="PRO_0000108089"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11851 MW;  41ECBB54ABB00971 CRC64;
     MPYLYLLLSI VSEVIGSAFL KSSDGFSKLY PTITTIISFL ICFYFLSKTM QHLPLNITYA
     SWAGLGLVLT TIVSVLIFKE QINLISIISI ILIIFGVVLL NTFGSSH