ID   QAY_NEUCR               Reviewed;         537 AA.
AC   P11636; Q7RVA0;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Quinate permease;
DE   AltName: Full=Quinate transporter;
GN   Name=qa-y; ORFNames=NCU06026;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=2525625; DOI=10.1016/0022-2836(89)90438-5;
RA   Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J.,
RA   Case M.E., Giles N.H.;
RT   "DNA sequence, organization and regulation of the qa gene cluster of
RT   Neurospora crassa.";
RL   J. Mol. Biol. 207:15-34(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; X14603; CAA32752.1; -; Genomic_DNA.
DR   EMBL; CM002242; EAA30380.1; -; Genomic_DNA.
DR   PIR; S04254; G31277.
DR   RefSeq; XP_959616.1; XM_954523.2.
DR   AlphaFoldDB; P11636; -.
DR   SMR; P11636; -.
DR   STRING; 5141.EFNCRP00000005335; -.
DR   TCDB; 2.A.1.1.7; the major facilitator superfamily (mfs).
DR   PRIDE; P11636; -.
DR   EnsemblFungi; EAA30380; EAA30380; NCU06026.
DR   GeneID; 3875775; -.
DR   KEGG; ncr:NCU06026; -.
DR   VEuPathDB; FungiDB:NCU06026; -.
DR   HOGENOM; CLU_001265_30_12_1; -.
DR   InParanoid; P11636; -.
DR   OMA; KVQWRFF; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   GO; GO:0019630; P:quinate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Quinate metabolism; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..537
FT                   /note="Quinate permease"
FT                   /id="PRO_0000050449"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..74
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..131
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..160
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..349
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        350..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        374..389
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        411..435
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        457..458
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        480..537
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          514..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        481
FT                   /note="E -> V (in Ref. 1; CAA32752)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   537 AA;  60134 MW;  89D53413EFC164F3 CRC64;
     MTLLALKEDR PTPKAVYNWR VYTCAAIASF ASCMIGYDSA FIGTTLALPS FTKEFDFASY
     TPGALALLQS NIVSVYQAGA FFGCLFAYAT SYFLGRRKSL IAFSVVFIIG AAIMLAADGQ
     GRGIDPIIAG RVLAGIGVGG ASNMVPIYIS ELAPPAVRGR LVGIYELGWQ IGGLVGFWIN
     YGVNTTMAPT RSQWLIPFAV QLIPAGLLFL GSFWIPESPR WLYANGKREE AMKVLCWIRN
     LEPTDRYIVQ EVSFIDADLE RYTRQVGNGF WKPFLSLKQR KVQWRFFLGG MLFFWQNGSG
     INAINYYSPT VFRSIGITGT DTGFLTTGIF GVVKMVLTII WLLWLVDLVG RRRILFIGAA
     GGSLCMWFIG AYIKIADPGS NKAEDAKLTS GGIAAIFFFY LWTAFYTPSW NGTPWVINSE
     MFDQNTRSLG QASAAANNWF WNFIISRFTP QMFIKMEYGV YFFFASLMLL SIVFIYFFLP
     ETKSIPLEAM DRLFEIKPVQ NANKNLMAEL NFDRNPEREE SSSLDDKDRV TQTENAV