QCR6L_HUMAN
ID QCR6L_HUMAN Reviewed; 91 AA.
AC A0A096LP55;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Cytochrome b-c1 complex subunit 6-like, mitochondrial {ECO:0000305};
DE Flags: Precursor;
GN Name=UQCRHL {ECO:0000312|HGNC:HGNC:51714};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a component of the ubiquinol-cytochrome c reductase
CC complex (complex III or cytochrome b-c1 complex), which is part of the
CC mitochondrial respiratory chain. This protein may mediate formation of
CC the complex between cytochromes c and c1.
CC {ECO:0000250|UniProtKB:P00127}.
CC -!- SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits
CC (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins
CC (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins
CC (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a
CC cleavage product of Rieske/UQCRFS1). {ECO:0000250|UniProtKB:P00127}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P00127}.
CC -!- SIMILARITY: Belongs to the UQCRH/QCR6 family.
CC {ECO:0000255|PIRNR:PIRNR000019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL450998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51754.1; -; Genomic_DNA.
DR CCDS; CCDS76112.1; -.
DR RefSeq; NP_001083060.1; NM_001089591.1.
DR AlphaFoldDB; A0A096LP55; -.
DR SMR; A0A096LP55; -.
DR IntAct; A0A096LP55; 3.
DR STRING; 9606.ENSP00000485401; -.
DR iPTMnet; A0A096LP55; -.
DR PhosphoSitePlus; A0A096LP55; -.
DR BioMuta; UQCRHL; -.
DR jPOST; A0A096LP55; -.
DR MassIVE; A0A096LP55; -.
DR MaxQB; A0A096LP55; -.
DR PeptideAtlas; A0A096LP55; -.
DR DNASU; 440567; -.
DR Ensembl; ENST00000483273.2; ENSP00000485401.1; ENSG00000233954.6.
DR GeneID; 440567; -.
DR KEGG; hsa:440567; -.
DR UCSC; uc009vol.2; human.
DR CTD; 440567; -.
DR DisGeNET; 440567; -.
DR GeneCards; UQCRHL; -.
DR HGNC; HGNC:51714; UQCRHL.
DR HPA; ENSG00000233954; Tissue enhanced (heart).
DR neXtProt; NX_A0A096LP55; -.
DR OpenTargets; ENSG00000233954; -.
DR VEuPathDB; HostDB:ENSG00000233954; -.
DR eggNOG; KOG4763; Eukaryota.
DR GeneTree; ENSGT00390000003860; -.
DR HOGENOM; CLU_115913_3_0_1; -.
DR OMA; QWRDRCA; -.
DR OrthoDB; 1621720at2759; -.
DR PathwayCommons; A0A096LP55; -.
DR SignaLink; A0A096LP55; -.
DR BioGRID-ORCS; 440567; 16 hits in 179 CRISPR screens.
DR ChiTaRS; UQCRHL; human.
DR GenomeRNAi; 440567; -.
DR Pharos; A0A096LP55; Tdark.
DR PRO; PR:A0A096LP55; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A0A096LP55; protein.
DR Bgee; ENSG00000233954; Expressed in ganglionic eminence and 99 other tissues.
DR GO; GO:0005750; C:mitochondrial respiratory chain complex III; IBA:GO_Central.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR Gene3D; 1.10.287.20; -; 1.
DR InterPro; IPR003422; Cyt_b-c1_6.
DR InterPro; IPR023184; Ubol_cytC_Rdtase_hinge_dom.
DR InterPro; IPR036811; Ubol_cytC_Rdtase_hinge_dom_sf.
DR PANTHER; PTHR15336; PTHR15336; 1.
DR Pfam; PF02320; UCR_hinge; 1.
DR PIRSF; PIRSF000019; Bc1_11K; 1.
DR SUPFAM; SSF81531; SSF81531; 1.
PE 3: Inferred from homology;
KW Acetylation; Disulfide bond; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transit peptide; Transport.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:P99028"
FT CHAIN 14..91
FT /note="Cytochrome b-c1 complex subunit 6-like,
FT mitochondrial"
FT /id="PRO_0000435432"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P99028"
FT MOD_RES 85
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P99028"
FT DISULFID 37..81
FT /evidence="ECO:0000250|UniProtKB:P00126"
SQ SEQUENCE 91 AA; 10752 MW; 2A495D12212746F3 CRC64;
MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELYDEHVSSR
SHTEEDCTEE LFDFLHAKDH CVAHKLFNNL K
