ID   QCR6_SOLTU              Reviewed;          69 AA.
AC   P48504;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Cytochrome b-c1 complex subunit 6;
DE   AltName: Full=CR7;
DE   AltName: Full=Complex III subunit 6;
DE   AltName: Full=Complex III subunit VI;
DE   AltName: Full=Mitochondrial hinge protein;
DE   AltName: Full=Ubiquinol-cytochrome c reductase complex 7.8 kDa protein;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-19.
RC   STRAIN=cv. Desiree; TISSUE=Tuber;
RX   PubMed=8013669; DOI=10.1016/0014-5793(94)00515-x;
RA   Braun H.-P., Jaensch L., Kruft V., Schmitz U.K.;
RT   "The 'Hinge' protein of cytochrome c reductase from potato lacks the acidic
RT   domain and has no cleavable presequence.";
RL   FEBS Lett. 347:90-94(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-18; 44-68 AND 63-69.
RC   STRAIN=cv. Hansa; TISSUE=Tuber;
RX   PubMed=7764624; DOI=10.1007/bf00191612;
RA   Braun H.-P., Kruft V., Schmitz U.K.;
RT   "Molecular identification of the ten subunits of cytochrome-c reductase
RT   from potato mitochondria.";
RL   Planta 193:99-106(1994).
CC   -!- FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a
CC       multisubunit transmembrane complex that is part of the mitochondrial
CC       electron transport chain which drives oxidative phosphorylation. The
CC       respiratory chain contains 3 multisubunit complexes succinate
CC       dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase
CC       (complex IV, CIV), that cooperate to transfer electrons derived from
CC       NADH and succinate to molecular oxygen, creating an electrochemical
CC       gradient over the inner membrane that drives transmembrane transport
CC       and the ATP synthase. The cytochrome b-c1 complex catalyzes electron
CC       transfer from ubiquinol to cytochrome c, linking this redox reaction to
CC       translocation of protons across the mitochondrial inner membrane, with
CC       protons being carried across the membrane as hydrogens on the quinol.
CC       In the process called Q cycle, 2 protons are consumed from the matrix,
CC       4 protons are released into the intermembrane space and 2 electrons are
CC       passed to cytochrome c. {ECO:0000250|UniProtKB:P00127}.
CC   -!- SUBUNIT: Component of the ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme
CC       composed of 3 respiratory subunits cytochrome b, cytochrome c1 and
CC       Rieske protein, 2 core protein subunits, and additional low-molecular
CC       weight protein subunits. The complex exists as an obligatory dimer and
CC       forms supercomplexes (SCs) in the inner mitochondrial membrane with
CC       cytochrome c oxidase (complex IV, CIV). {ECO:0000250|UniProtKB:P00127}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P00127}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P00127}; Intermembrane side
CC       {ECO:0000250|UniProtKB:P00127}.
CC   -!- DOMAIN: Lacks the acidic domain of other UQCRH.
CC   -!- SIMILARITY: Belongs to the UQCRH/QCR6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X79273; CAA55860.1; -; mRNA.
DR   PIR; S48690; S48690.
DR   AlphaFoldDB; P48504; -.
DR   SMR; P48504; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; P48504; baseline and differential.
DR   GO; GO:0005750; C:mitochondrial respiratory chain complex III; IBA:GO_Central.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR   Gene3D; 1.10.287.20; -; 1.
DR   InterPro; IPR003422; Cyt_b-c1_6.
DR   InterPro; IPR023184; Ubol_cytC_Rdtase_hinge_dom.
DR   InterPro; IPR036811; Ubol_cytC_Rdtase_hinge_dom_sf.
DR   PANTHER; PTHR15336; PTHR15336; 1.
DR   Pfam; PF02320; UCR_hinge; 1.
DR   PIRSF; PIRSF000019; Bc1_11K; 1.
DR   SUPFAM; SSF81531; SSF81531; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Electron transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Respiratory chain; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:7764624,
FT                   ECO:0000269|PubMed:8013669"
FT   CHAIN           2..69
FT                   /note="Cytochrome b-c1 complex subunit 6"
FT                   /id="PRO_0000193541"
FT   DISULFID        17..59
FT                   /evidence="ECO:0000250|UniProtKB:P00126"
FT   DISULFID        31..45
FT                   /evidence="ECO:0000250|UniProtKB:P00127"
SQ   SEQUENCE   69 AA;  7977 MW;  EA977D9E3D8A93E5 CRC64;
     MSDEEVVDPK ATLEVSCKPK CVRQLKEYQA CTKRVEGDES GHKHCTGQYF DYWHCIDKCV
     AAKLFDHLK