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QCR8_SCHPO
ID   QCR8_SCHPO              Reviewed;          92 AA.
AC   P50523;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Cytochrome b-c1 complex subunit 8;
DE   AltName: Full=Complex III subunit 8;
DE   AltName: Full=Ubiquinol-cytochrome c reductase complex 11 kDa protein;
DE   AltName: Full=Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C;
GN   Name=qcr8; ORFNames=SPAC1782.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7748888; DOI=10.1016/0005-2728(95)00035-h;
RA   Boumans H., Berden J.A., Grivell L.A.;
RT   "cDNA sequence of subunit VIII of ubiquinol-cytochrome-c oxidoreductase
RT   from Schizosaccharomyces pombe.";
RL   Biochim. Biophys. Acta 1229:386-388(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a
CC       multisubunit transmembrane complex that is part of the mitochondrial
CC       electron transport chain which drives oxidative phosphorylation. The
CC       respiratory chain contains 3 multisubunit complexes succinate
CC       dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase
CC       (complex IV, CIV), that cooperate to transfer electrons derived from
CC       NADH and succinate to molecular oxygen, creating an electrochemical
CC       gradient over the inner membrane that drives transmembrane transport
CC       and the ATP synthase. The cytochrome b-c1 complex catalyzes electron
CC       transfer from ubiquinol to cytochrome c, linking this redox reaction to
CC       translocation of protons across the mitochondrial inner membrane, with
CC       protons being carried across the membrane as hydrogens on the quinol.
CC       In the process called Q cycle, 2 protons are consumed from the matrix,
CC       4 protons are released into the intermembrane space and 2 electrons are
CC       passed to cytochrome c. {ECO:0000250|UniProtKB:P08525}.
CC   -!- SUBUNIT: Component of the ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme
CC       composed of 3 respiratory subunits cytochrome b, cytochrome c1 and
CC       Rieske protein, 2 core protein subunits, and additional low-molecular
CC       weight protein subunits. The complex exists as an obligatory dimer and
CC       forms supercomplexes (SCs) in the inner mitochondrial membrane with
CC       cytochrome c oxidase (complex IV, CIV). {ECO:0000250|UniProtKB:P08525}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P08525}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P08525}.
CC   -!- SIMILARITY: Belongs to the UQCRQ/QCR8 family. {ECO:0000305}.
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DR   EMBL; U18794; AAA85691.1; -; mRNA.
DR   EMBL; CU329670; CAB76269.1; -; Genomic_DNA.
DR   PIR; T50097; T50097.
DR   RefSeq; NP_594714.1; NM_001020141.2.
DR   AlphaFoldDB; P50523; -.
DR   SMR; P50523; -.
DR   BioGRID; 278822; 38.
DR   STRING; 4896.SPAC1782.07.1; -.
DR   MaxQB; P50523; -.
DR   PaxDb; P50523; -.
DR   EnsemblFungi; SPAC1782.07.1; SPAC1782.07.1:pep; SPAC1782.07.
DR   GeneID; 2542357; -.
DR   KEGG; spo:SPAC1782.07; -.
DR   PomBase; SPAC1782.07; qcr8.
DR   VEuPathDB; FungiDB:SPAC1782.07; -.
DR   eggNOG; KOG4116; Eukaryota.
DR   HOGENOM; CLU_156007_0_1_1; -.
DR   InParanoid; P50523; -.
DR   OMA; AAIFNTW; -.
DR   PhylomeDB; P50523; -.
DR   Reactome; R-SPO-611105; Respiratory electron transport.
DR   PRO; PR:P50523; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005750; C:mitochondrial respiratory chain complex III; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IGI:PomBase.
DR   Gene3D; 1.20.5.210; -; 1.
DR   InterPro; IPR004205; Cyt_bc1_su8.
DR   InterPro; IPR036642; Cyt_bc1_su8_sf.
DR   PANTHER; PTHR12119; PTHR12119; 1.
DR   Pfam; PF02939; UcrQ; 1.
DR   SUPFAM; SSF81508; SSF81508; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..92
FT                   /note="Cytochrome b-c1 complex subunit 8"
FT                   /id="PRO_0000193550"
FT   TOPO_DOM        1..50
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P08525"
FT   TRANSMEM        51..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P08525"
FT   TOPO_DOM        82..92
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P08525"
SQ   SEQUENCE   92 AA;  10467 MW;  B5FD6B6013D39E54 CRC64;
     MGGAAGGKTY LGWWGHLGGP KQKGIITYSL SPFQQRPMAG FFKTSTQNMF RRVMTEGLYV
     AIPFGIAYYI YCWGKERNEF LNSKHGRHLV EE
 
 
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