QCR8_SOLTU
ID QCR8_SOLTU Reviewed; 72 AA.
AC P46269;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Cytochrome b-c1 complex subunit 8;
DE AltName: Full=Complex III subunit 8;
DE AltName: Full=Complex III subunit VII;
DE AltName: Full=Ubiquinol-cytochrome c reductase complex 8.2 kDa protein;
DE AltName: Full=Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C;
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-28.
RC STRAIN=cv. Bintje; TISSUE=Tuber;
RX PubMed=7803451; DOI=10.1016/0005-2728(94)90057-4;
RA Braun H.-P., Kruft V., Schmitz U.K.;
RT "Primary structure, cell-free synthesis and mitochondrial targeting of the
RT 8.2 kDa protein of cytochrome c reductase from potato.";
RL Biochim. Biophys. Acta 1188:367-372(1994).
RN [2]
RP PROTEIN SEQUENCE OF 9-28 AND 67-72.
RC STRAIN=cv. Hansa; TISSUE=Tuber;
RX PubMed=7764624; DOI=10.1007/bf00191612;
RA Braun H.-P., Kruft V., Schmitz U.K.;
RT "Molecular identification of the ten subunits of cytochrome-c reductase
RT from potato mitochondria.";
RL Planta 193:99-106(1994).
CC -!- FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a
CC multisubunit transmembrane complex that is part of the mitochondrial
CC electron transport chain which drives oxidative phosphorylation. The
CC respiratory chain contains 3 multisubunit complexes succinate
CC dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase
CC (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase
CC (complex IV, CIV), that cooperate to transfer electrons derived from
CC NADH and succinate to molecular oxygen, creating an electrochemical
CC gradient over the inner membrane that drives transmembrane transport
CC and the ATP synthase. The cytochrome b-c1 complex catalyzes electron
CC transfer from ubiquinol to cytochrome c, linking this redox reaction to
CC translocation of protons across the mitochondrial inner membrane, with
CC protons being carried across the membrane as hydrogens on the quinol.
CC In the process called Q cycle, 2 protons are consumed from the matrix,
CC 4 protons are released into the intermembrane space and 2 electrons are
CC passed to cytochrome c. {ECO:0000250|UniProtKB:P08525}.
CC -!- SUBUNIT: Component of the ubiquinol-cytochrome c oxidoreductase
CC (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme
CC composed of 3 respiratory subunits cytochrome b, cytochrome c1 and
CC Rieske protein, 2 core protein subunits, and additional low-molecular
CC weight protein subunits. The complex exists as an obligatory dimer and
CC forms supercomplexes (SCs) in the inner mitochondrial membrane with
CC cytochrome c oxidase (complex IV, CIV). {ECO:0000250|UniProtKB:P08525}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P08525}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P08525}.
CC -!- SIMILARITY: Belongs to the UQCRQ/QCR8 family. {ECO:0000305}.
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DR EMBL; X79275; CAA55862.1; -; mRNA.
DR PIR; T07370; T07370.
DR AlphaFoldDB; P46269; -.
DR SMR; P46269; -.
DR STRING; 4113.PGSC0003DMT400078304; -.
DR PRIDE; P46269; -.
DR EnsemblPlants; RHC06H1G0355.2.1; RHC06H1G0355.2.1; RHC06H1G0355.2.
DR Gramene; RHC06H1G0355.2.1; RHC06H1G0355.2.1; RHC06H1G0355.2.
DR eggNOG; ENOG502S4G5; Eukaryota.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; P46269; baseline and differential.
DR GO; GO:0005750; C:mitochondrial respiratory chain complex III; IEA:InterPro.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:InterPro.
DR Gene3D; 1.20.5.210; -; 1.
DR InterPro; IPR020101; Cyt_b-c1_8-plants.
DR InterPro; IPR036642; Cyt_bc1_su8_sf.
DR PANTHER; PTHR34559; PTHR34559; 1.
DR Pfam; PF10890; Cyt_b-c1_8; 1.
DR SUPFAM; SSF81508; SSF81508; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7803451"
FT CHAIN 2..72
FT /note="Cytochrome b-c1 complex subunit 8"
FT /id="PRO_0000193548"
FT TOPO_DOM 2..41
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P08525"
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..72
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P08525"
FT CONFLICT 15
FT /note="I -> L (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 72 AA; 8317 MW; 3AC5C12019223DA6 CRC64;
MGKQPVKLKA VVYAISPFQQ KIMPGLWKDL PGKIHHKVSE NWISATLLLG PLVGTYSYVQ
HFLEKEKLEH RY