QCRC_BACSU
ID QCRC_BACSU Reviewed; 255 AA.
AC P46913;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Menaquinol-cytochrome c reductase cytochrome b/c subunit;
GN Name=qcrC; Synonyms=bfcC; OrderedLocusNames=BSU22540;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BR151;
RX PubMed=7592464; DOI=10.1128/jb.177.23.6751-6760.1995;
RA Yu J., Hederstedt L., Piggot P.J.;
RT "The cytochrome bc complex (menaquinone:cytochrome c reductase) in Bacillus
RT subtilis has a nontraditional subunit organization.";
RL J. Bacteriol. 177:6751-6760(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA Serror P.;
RT "Sequence analysis of the Bacillus subtilis chromosome region between the
RT serA and kdg loci cloned in a yeast artificial chromosome.";
RL Microbiology 142:2005-2016(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Component of the menaquinol-cytochrome c reductase complex.
CC -!- SUBUNIT: The main subunits of the menaquinone:cytochrome c complex are:
CC cytochrome b, the Rieske protein and a cytochrome b/c subunit.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome b family. {ECO:0000255|PROSITE-
CC ProRule:PRU00967}.
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DR EMBL; U25535; AAA85562.1; -; Genomic_DNA.
DR EMBL; L47709; AAB38437.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14170.1; -; Genomic_DNA.
DR PIR; D69687; D69687.
DR RefSeq; NP_390135.1; NC_000964.3.
DR RefSeq; WP_003225562.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P46913; -.
DR STRING; 224308.BSU22540; -.
DR TCDB; 3.D.3.4.1; the proton-translocating quinol:cytochrome c reductase (qcr) superfamily.
DR PaxDb; P46913; -.
DR EnsemblBacteria; CAB14170; CAB14170; BSU_22540.
DR GeneID; 64304034; -.
DR GeneID; 939021; -.
DR KEGG; bsu:BSU22540; -.
DR PATRIC; fig|224308.179.peg.2458; -.
DR eggNOG; COG1290; Bacteria.
DR eggNOG; COG2010; Bacteria.
DR InParanoid; P46913; -.
DR OMA; DKNAEGY; -.
DR PhylomeDB; P46913; -.
DR BioCyc; BSUB:BSU22540-MON; -.
DR BioCyc; MetaCyc:BSU22540-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR Gene3D; 1.10.760.10; -; 1.
DR Gene3D; 1.20.810.10; -; 1.
DR InterPro; IPR005798; Cyt_b/b6_C.
DR InterPro; IPR036150; Cyt_b/b6_C_sf.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR027387; Cytb/b6-like_sf.
DR InterPro; IPR012049; MenaQ_cyt_c_Rdtase_cyt_b/c-su.
DR Pfam; PF00032; Cytochrom_B_C; 1.
DR Pfam; PF13442; Cytochrome_CBB3; 1.
DR PIRSF; PIRSF036636; QcrC; 1.
DR SUPFAM; SSF46626; SSF46626; 1.
DR SUPFAM; SSF81648; SSF81648; 1.
DR PROSITE; PS51003; CYTB_CTER; 1.
DR PROSITE; PS51007; CYTC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..255
FT /note="Menaquinol-cytochrome c reductase cytochrome b/c
FT subunit"
FT /id="PRO_0000061920"
FT TRANSMEM 46..62
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00967"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00967"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00967"
FT DOMAIN 178..255
FT /note="Cytochrome c"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 192
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 195
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 196
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
SQ SEQUENCE 255 AA; 28162 MW; 648734036FE96CE6 CRC64;
MHRGKGMKFV GDSRIPAEKK PNIPKDYSEY PGKTEAFWPN FLLKEWMVGA VFLIGFLVLT
IVHQPPLERM ADPTDTGYIP LPDWYFLFLY QLLKYEYAAG SFTVVGAMIM PGLAFGALLL
APFLDRGTER RPWKRPVAVG MMLLAISAAV FLTWQSVATH DWAKAEEQGK ITKEADIDTN
AEGYKVFKEQ GCISCHGDNL QGGAAGPSLV DSGLKPDEIK KIAVEGKGKM PAGVFKGNDK
QLEELAKFIS ETTAK
