QDR1_CANAL
ID QDR1_CANAL Reviewed; 509 AA.
AC Q5A6P6; A0A1D8PSR1;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=MFS antiporter QDR1 {ECO:0000305};
GN Name=QDR; OrderedLocusNames=CAALFM_CR04210CA;
GN ORFNames=CaO19.508, CaO19.8138;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=11737641; DOI=10.1046/j.1365-2958.2001.02713.x;
RA Murad A.M., d'Enfert C., Gaillardin C., Tournu H., Tekaia F., Talibi D.,
RA Marechal D., Marchais V., Cottin J., Brown A.J.;
RT "Transcript profiling in Candida albicans reveals new cellular functions
RT for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.";
RL Mol. Microbiol. 42:981-993(2001).
RN [5]
RP INDUCTION.
RX PubMed=12397174; DOI=10.1073/pnas.232566499;
RA Lan C.Y., Newport G., Murillo L.A., Jones T., Scherer S., Davis R.W.,
RA Agabian N.;
RT "Metabolic specialization associated with phenotypic switching in
RT Candidaalbicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14907-14912(2002).
RN [6]
RP INDUCTION.
RX PubMed=15917516; DOI=10.1128/aac.49.6.2226-2236.2005;
RA Liu T.T., Lee R.E., Barker K.S., Lee R.E., Wei L., Homayouni R.,
RA Rogers P.D.;
RT "Genome-wide expression profiling of the response to azole, polyene,
RT echinocandin, and pyrimidine antifungal agents in Candida albicans.";
RL Antimicrob. Agents Chemother. 49:2226-2236(2005).
RN [7]
RP IDENTIFICATION.
RX PubMed=19055746; DOI=10.1186/1471-2164-9-579;
RA Gaur M., Puri N., Manoharlal R., Rai V., Mukhopadhayay G., Choudhury D.,
RA Prasad R.;
RT "MFS transportome of the human pathogenic yeast Candida albicans.";
RL BMC Genomics 9:579-579(2008).
RN [8]
RP INDUCTION.
RX PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL J. Biol. Chem. 286:25154-25170(2011).
RN [9]
RP INDUCTION.
RX PubMed=23613980; DOI=10.1371/journal.pone.0061940;
RA Palige K., Linde J., Martin R., Bottcher B., Citiulo F., Sullivan D.J.,
RA Weber J., Staib C., Rupp S., Hube B., Morschhauser J., Staib P.;
RT "Global transcriptome sequencing identifies chlamydospore specific markers
RT in Candida albicans and Candida dubliniensis.";
RL PLoS ONE 8:E61940-E61940(2013).
RN [10]
RP SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=24621232; DOI=10.1042/bj20140010;
RA Shah A.H., Singh A., Dhamgaye S., Chauhan N., Vandeputte P., Suneetha K.J.,
RA Kaur R., Mukherjee P.K., Chandra J., Ghannoum M.A., Sanglard D.,
RA Goswami S.K., Prasad R.;
RT "Novel role of a family of major facilitator transporters in biofilm
RT development and virulence of Candida albicans.";
RL Biochem. J. 460:223-235(2014).
CC -!- FUNCTION: MFS antiporter that does not display functional linkage as
CC drug transporter and performs functions that significantly affect
CC biofilm development and virulence. No substrate for transport has been
CC identified yet, but plays an important role in the growth in the host.
CC {ECO:0000269|PubMed:24621232}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24621232};
CC Multi-pass membrane protein {ECO:0000269|PubMed:24621232}.
CC Note=Preferentially localizes to membrane rafts.
CC {ECO:0000269|PubMed:24621232, ECO:0000303|PubMed:19055746}.
CC -!- INDUCTION: Expression is repressed by caspofungin and during
CC chlamydospore formation. Also regulated during white-opaque switch, and
CC by NRG1, TUP1 and HAP43. {ECO:0000269|PubMed:11737641,
CC ECO:0000269|PubMed:12397174, ECO:0000269|PubMed:15917516,
CC ECO:0000269|PubMed:21592964, ECO:0000269|PubMed:23613980}.
CC -!- DISRUPTION PHENOTYPE: Leads to defects in biofilm architecture.
CC {ECO:0000269|PubMed:24621232}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; CP017630; AOW31159.1; -; Genomic_DNA.
DR RefSeq; XP_717371.1; XM_712278.2.
DR AlphaFoldDB; Q5A6P6; -.
DR SMR; Q5A6P6; -.
DR STRING; 237561.Q5A6P6; -.
DR PRIDE; Q5A6P6; -.
DR GeneID; 3640941; -.
DR KEGG; cal:CAALFM_CR04210CA; -.
DR CGD; CAL0000179875; QDR1.
DR VEuPathDB; FungiDB:CR_04210C_A; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_8_4_1; -.
DR InParanoid; Q5A6P6; -.
DR OMA; KYDNPDY; -.
DR OrthoDB; 552415at2759; -.
DR PRO; PR:Q5A6P6; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:CGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IMP:CGD.
DR GO; GO:0001765; P:membrane raft assembly; IMP:CGD.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Virulence.
FT CHAIN 1..509
FT /note="MFS antiporter QDR1"
FT /id="PRO_0000431599"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..75
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 107..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..132
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 133..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 170..190
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..197
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 198..218
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..312
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 313..333
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 371..391
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..397
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 398..418
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 433..453
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 454..455
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 456..476
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 509 AA; 55432 MW; 612FFB8DA3E57073 CRC64;
MPGNREEFDI EKVLKSKKLE AIETSTEKKA PYTVFESTDK LLLIIVLSLV GFWSAISSPI
YFPALPTLTK YFNTTPSVMN ISVVAYLIFQ GIAPTISSNL ADTFGRRPVI LGSIIVFCAV
CIAISQTNVY WLLALLRCFQ AAGIAPVFAI SSGVAGDICT PANRGGMVGA VSGLQLAGNG
IGGLVGAALI SGFHTWRAIF IFLAIGGGVT FIFAFLVLAE TSRRIVGNGS IRPKNVLNKA
VLIYLPHFKN KITNDYSTLQ PKGPFDILGP FKIFFQKEVF CTLLPSGMHF AAWTVSLTSL
STELESAKYN YSVMKVGLVY LPQGIACFIG SLIAGRCLNW YYRYRKNLYD KQMNDVPLND
RPPFNLVASR LTLTIVPLAM MVIGLSAFGW CLEYKKPIIS IIISTILISF SASVMMSICT
TMLVDLYPKQ SGASASCVNL MRCWLAALFT GVLDKIISAL GLGGTYTLLT GICLLTDLGL
VYVLYTANQR FVNYVSPNQT AVNSDAEDY
