QDR2_CANAL
ID QDR2_CANAL Reviewed; 504 AA.
AC Q59YT1; A0A1D8PKF5;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=MFS antiporter QDR2 {ECO:0000305};
GN Name=QDR2; OrderedLocusNames=CAALFM_C305570WA; ORFNames=CaO19.6992;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=19055746; DOI=10.1186/1471-2164-9-579;
RA Gaur M., Puri N., Manoharlal R., Rai V., Mukhopadhayay G., Choudhury D.,
RA Prasad R.;
RT "MFS transportome of the human pathogenic yeast Candida albicans.";
RL BMC Genomics 9:579-579(2008).
RN [5]
RP SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=24621232; DOI=10.1042/bj20140010;
RA Shah A.H., Singh A., Dhamgaye S., Chauhan N., Vandeputte P., Suneetha K.J.,
RA Kaur R., Mukherjee P.K., Chandra J., Ghannoum M.A., Sanglard D.,
RA Goswami S.K., Prasad R.;
RT "Novel role of a family of major facilitator transporters in biofilm
RT development and virulence of Candida albicans.";
RL Biochem. J. 460:223-235(2014).
CC -!- FUNCTION: MFS antiporter that does not display functional linkage as
CC drug transporter and performs functions that significantly affect
CC biofilm development and virulence. No substrate for transport has been
CC identified yet, but plays an important role in the growth in the host.
CC {ECO:0000269|PubMed:24621232}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24621232};
CC Multi-pass membrane protein {ECO:0000269|PubMed:24621232}.
CC Note=Preferentially localizes to membrane rafts.
CC {ECO:0000269|PubMed:24621232, ECO:0000303|PubMed:19055746}.
CC -!- DISRUPTION PHENOTYPE: Leads to defects in biofilm architecture and
CC attenuated virulence. {ECO:0000269|PubMed:24621232}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; CP017625; AOW28568.1; -; Genomic_DNA.
DR RefSeq; XP_714698.1; XM_709605.1.
DR AlphaFoldDB; Q59YT1; -.
DR SMR; Q59YT1; -.
DR STRING; 237561.Q59YT1; -.
DR GeneID; 3643661; -.
DR KEGG; cal:CAALFM_C305570WA; -.
DR CGD; CAL0000179742; QDR2.
DR VEuPathDB; FungiDB:C3_05570W_A; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_8_4_1; -.
DR InParanoid; Q59YT1; -.
DR OMA; CICASMV; -.
DR OrthoDB; 552415at2759; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:CGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IMP:CGD.
DR GO; GO:0001765; P:membrane raft assembly; IMP:CGD.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Virulence.
FT CHAIN 1..504
FT /note="MFS antiporter QDR2"
FT /id="PRO_0000431600"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..75
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 107..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..132
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 133..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 170..190
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..198
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 199..219
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..311
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 312..332
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 371..391
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..396
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 397..417
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..438
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 439..456
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..460
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 461..483
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 484..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 54897 MW; 626CC2DD444FF496 CRC64;
MLSTTQSVTE PTEVTSKKVE DIEKENDEET PYSIFTSYDR LVLIVILSLI GFWSTISSPI
YFPALPTLTS YFHTSSSIMN ISVVAYLIFQ GIAPTISSNL ADTFGRRPVI LASIIVFCAS
CVAISQTNVY WLLAVLRCIQ AAGIAAVISI SSGVAGDVCT RANRGSMVGA VAGLQLVGNG
IGGLVGAALI SSFNSWRSIF IFLTIGGGVT FILAIFILPE TSRKLVGNGS VVPKNILNKS
PYIYLPHFKK RMNNDITTIV PATRFDLLGP LKIFFQKNVF CTLLPVGIHF AAWTMVLTSL
STELESRYHY SVMHVGLIYL PQGIACIAGS LVVGKSLDWY YRYRKTIYDQ EVECLPLDER
PQFNIVATRL TLSVVPALLM IIGLVIFGWC IQYKRHIISI IISTILVSFS ASVFIAICTT
MLVDLYPNNG SGSTSCLNLM RCWLAALGAG VLDSMINAMN VGGTYTVVAG FCILFDLALI
YVLHNAKKKF SNSGPTTTKS PPKQ
