QDR3_CANAL
ID QDR3_CANAL Reviewed; 697 AA.
AC Q59XM0; A0A1D8PPL8; Q59WR8;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=MFS antiporter QDR3 {ECO:0000305};
GN Name=QDR3; OrderedLocusNames=CAALFM_C601290CA;
GN ORFNames=CaO19.136, CaO19.7780;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=19055746; DOI=10.1186/1471-2164-9-579;
RA Gaur M., Puri N., Manoharlal R., Rai V., Mukhopadhayay G., Choudhury D.,
RA Prasad R.;
RT "MFS transportome of the human pathogenic yeast Candida albicans.";
RL BMC Genomics 9:579-579(2008).
RN [5]
RP INDUCTION.
RX PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL J. Biol. Chem. 286:25154-25170(2011).
RN [6]
RP SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=24621232; DOI=10.1042/bj20140010;
RA Shah A.H., Singh A., Dhamgaye S., Chauhan N., Vandeputte P., Suneetha K.J.,
RA Kaur R., Mukherjee P.K., Chandra J., Ghannoum M.A., Sanglard D.,
RA Goswami S.K., Prasad R.;
RT "Novel role of a family of major facilitator transporters in biofilm
RT development and virulence of Candida albicans.";
RL Biochem. J. 460:223-235(2014).
CC -!- FUNCTION: MFS antiporter that does not display functional linkage as
CC drug transporter and performs functions that significantly affect
CC biofilm development and virulence. No substrate for transport has been
CC identified yet, but plays an important role in the growth in the host.
CC {ECO:0000269|PubMed:24621232, ECO:0000303|PubMed:19055746}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24621232};
CC Multi-pass membrane protein {ECO:0000269|PubMed:24621232}. Note=In
CC contrast to QDR1 and QDR2, does not accumulate in membrane rafts and
CC shows uniform distribution at the cell membrane.
CC {ECO:0000269|PubMed:24621232}.
CC -!- INDUCTION: Expression is repressed by HAP43.
CC {ECO:0000269|PubMed:21592964}.
CC -!- DISRUPTION PHENOTYPE: Leads to defects in biofilm architecture and
CC attenuated virulence. {ECO:0000269|PubMed:24621232}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; CP017628; AOW30070.1; -; Genomic_DNA.
DR RefSeq; XP_714342.2; XM_709249.2.
DR AlphaFoldDB; Q59XM0; -.
DR STRING; 237561.Q59XM0; -.
DR GeneID; 3644023; -.
DR KEGG; cal:CAALFM_C601290CA; -.
DR CGD; CAL0000174097; QDR3.
DR VEuPathDB; FungiDB:C6_01290C_A; -.
DR HOGENOM; CLU_008455_8_5_1; -.
DR InParanoid; Q59XM0; -.
DR OrthoDB; 956763at2759; -.
DR PRO; PR:Q59XM0; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0015203; F:polyamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030476; P:ascospore wall assembly; IEA:EnsemblFungi.
DR GO; GO:0010509; P:polyamine homeostasis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Virulence.
FT CHAIN 1..697
FT /note="MFS antiporter QDR3"
FT /id="PRO_0000431601"
FT TOPO_DOM 1..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..162
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..180
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 181..201
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 216..236
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..240
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 241..261
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..289
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..296
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 297..317
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..485
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 486..506
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 507..519
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 520..540
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 541..565
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 566..586
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 587..590
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 591..611
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 612..626
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 627..647
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..653
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 654..674
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 675..697
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 38..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 697 AA; 77198 MW; 1D9A55A4413F133C CRC64;
MSHSPNLSPQ ISNDIIDADT TSLASTETQQ NIQHSQIHPI GHHGREQSEE PQNTTKTTTT
TTNKIHTTTP SVDPDLGPLR ELEQDLSSLE SQQEQYLSQK PTSTSIKTNK VPLRERRGLL
AQIVLIPEYE DARDYPNKIK YLIVFIIAFA SLAGPFGTSV MLPAIDDIVN DLNTNVSTVN
VSVGIYLLSL GIFPLWWSSF SERFGRRSVY MVSFTLFVAF SIGTALSPNI AALIVLRVLQ
GGSSASVQAV GAGTIADLFI PQERGQAMGL YYLGPLAGPF LAPILGGAVS QAWGWRATQW
LLMIISACSF VLITFFLPET LRRVDTIQVA KDLMKKSDNN GSQNEKIHDD FAGADNSSVH
DIDGNPIPGT ELHQVVSNLS RRSSNARSIV TYMEEQENEG PIIDPVMPSI SRLTTNRSAY
SQRIHQNYVT DELRKTTSNL TQSNHSQYNN NNNNDNDKWS SVKTNCYDLI IRPLHSIILL
KHPPVVLVIS FSAISFAAIY FFNMAISYEY ARSPYNFSSV ILGLMYIPNS VTYFMASIIG
GKWNDRLLNR YAQKHGELVP ESRLSWNIVV AIILYPMACL IFGWTIKYRE FWVIPLIGTA
LFGFASMLVI GATVTYLVDS LPGKGATGVA LNNLIRQILA AIATFIVEPL LRAIGAGVLF
SIIAGILLVS SLVLLYLKKR GAFFREHYDV MDLYAKL
