ID   QKIB_DANRE              Reviewed;         319 AA.
AC   Q6P104; Q6P7D9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Protein quaking-B;
DE   AltName: Full=Quaking-related protein;
GN   Name=qkib; Synonyms=qkr; ORFNames=zgc:65890, zgc:77340;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Sugiyama T., Abe K., Yasuda K., Inoue K.;
RT   "Temporal and spatial expression of a novel quaking-related gene, qkr, in
RT   zebrafish.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that plays a central role in
CC       myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core
CC       sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA
CC       stability and protein translation. Required to protect and promote
CC       stability of mRNAs which promotes oligodendrocyte differentiation.
CC       Participates in mRNA transport by regulating the nuclear export of MBP
CC       mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA.
CC       Acts as a translational repressor (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Does not require RNA to homodimerize (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P104-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P104-2; Sequence=VSP_019205;
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DR   EMBL; AB086654; BAD23948.1; -; mRNA.
DR   EMBL; BC061709; AAH61709.1; -; mRNA.
DR   EMBL; BC065344; AAH65344.1; -; mRNA.
DR   RefSeq; NP_957136.2; NM_200842.2. [Q6P104-1]
DR   RefSeq; XP_005156412.1; XM_005156355.3. [Q6P104-2]
DR   AlphaFoldDB; Q6P104; -.
DR   SMR; Q6P104; -.
DR   STRING; 7955.ENSDARP00000020217; -.
DR   PaxDb; Q6P104; -.
DR   Ensembl; ENSDART00000027034; ENSDARP00000020217; ENSDARG00000010018. [Q6P104-1]
DR   GeneID; 393815; -.
DR   KEGG; dre:393815; -.
DR   CTD; 393815; -.
DR   ZFIN; ZDB-GENE-040426-1462; qki2.
DR   eggNOG; KOG1588; Eukaryota.
DR   GeneTree; ENSGT00940000155310; -.
DR   HOGENOM; CLU_046595_2_0_1; -.
DR   InParanoid; Q6P104; -.
DR   OrthoDB; 1565749at2759; -.
DR   PhylomeDB; Q6P104; -.
DR   TreeFam; TF314878; -.
DR   PRO; PR:Q6P104; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000010018; Expressed in brain and 42 other tissues.
DR   ExpressionAtlas; Q6P104; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0014866; P:skeletal myofibril assembly; IGI:ZFIN.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032377; STAR_dimer.
DR   PANTHER; PTHR11208; PTHR11208; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16544; STAR_dimer; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; SH3-binding; Translation regulation;
KW   Transport.
FT   CHAIN           1..319
FT                   /note="Protein quaking-B"
FT                   /id="PRO_0000239379"
FT   DOMAIN          87..153
FT                   /note="KH"
FT   MOTIF           276..279
FT                   /note="SH3-binding"
FT   VAR_SEQ         213
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_019205"
SQ   SEQUENCE   319 AA;  35256 MW;  B072D5CB218F3FF8 CRC64;
     MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIG RVRKDMYNDT
     LNGSTDKRTS ELPDAVGPIA QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
     IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDS QNRAEIKLKR AVEEVKKLLV
     PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAPRIMTG PTPVMPNAAL
     RTPAPTAPTL MPLIRQIQTS ALMPTGTPHP TATLLPQTPE SGIIYAPYDY PYALAPATSI
     LEYPIDSSGV LGMAFPTKG