ID   QKIB_XENLA              Reviewed;         342 AA.
AC   Q6IRN2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein quaking-B;
GN   Name=qki-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   STRUCTURE BY NMR OF 82-215.
RX   PubMed=15811367; DOI=10.1016/j.jmb.2005.02.058;
RA   Maguire M.L., Guler-Gane G., Nietlispach D., Raine A.R.C., Zorn A.M.,
RA   Standart N., Broadhurst R.W.;
RT   "Solution structure and backbone dynamics of the KH-QUA2 region of the
RT   Xenopus STAR/GSG quaking protein.";
RL   J. Mol. Biol. 348:265-279(2005).
CC   -!- FUNCTION: RNA-binding protein that plays a central role in
CC       myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core
CC       sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA
CC       stability and protein translation. Required to protect and promote
CC       stability of mRNAs which promotes oligodendrocyte differentiation.
CC       Participates in mRNA transport by regulating the nuclear export of MBP
CC       mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA.
CC       Acts as a translational repressor (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Does not require RNA to homodimerize (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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DR   EMBL; BC070801; AAH70801.1; -; mRNA.
DR   RefSeq; NP_001084987.1; NM_001091518.1.
DR   PDB; 2BL5; NMR; -; A=82-215.
DR   PDBsum; 2BL5; -.
DR   AlphaFoldDB; Q6IRN2; -.
DR   BMRB; Q6IRN2; -.
DR   SMR; Q6IRN2; -.
DR   DNASU; 432049; -.
DR   GeneID; 432049; -.
DR   KEGG; xla:432049; -.
DR   CTD; 432049; -.
DR   Xenbase; XB-GENE-865618; qki.L.
DR   OMA; PPCSCEC; -.
DR   OrthoDB; 1565749at2759; -.
DR   EvolutionaryTrace; Q6IRN2; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 432049; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032367; Quaking_NLS.
DR   InterPro; IPR032377; STAR_dimer.
DR   PANTHER; PTHR11208; PTHR11208; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16551; Quaking_NLS; 1.
DR   Pfam; PF16544; STAR_dimer; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Developmental protein; Differentiation;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; Translation regulation; Transport.
FT   CHAIN           1..342
FT                   /note="Protein quaking-B"
FT                   /id="PRO_0000239381"
FT   DOMAIN          88..154
FT                   /note="KH"
SQ   SEQUENCE   342 AA;  37943 MW;  629F3B6DA4D0ABA9 CRC64;
     MVGETETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFTH LERLLDEEIS RVRKDMYNDT
     LNGSNNEKRT NELPDGIGPI VQLQEKLYVP VKEYPDFNFV GRILGPRGLT AKQLEAETGC
     KIMVRGKGSM RDKKKEEQNR GKPNWEHLNE DLHVLITVED AQNRAEIKLK RAVEEVKKLL
     VPAAEGEDSL KKMQLMELAI LNGTYRDANL KSPALAFSLA ATAQAPRIIT GPAPVLPPAA
     LRTPTPAGPT LMPLIRQIQT ATVMPNGTPH PTATLMSQAP EAGLIYTPYE YPYTLAPATS
     ILEYPIETSG VLGAVATKVR RHDMRVHPYQ RIVTADRAAT GN