QKIL5_ARATH
ID QKIL5_ARATH Reviewed; 298 AA.
AC Q8GWR3; O04489; O04490; Q8W574;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=KH domain-containing protein At1g09660/At1g09670;
DE AltName: Full=Quaking-like protein 5;
GN OrderedLocusNames=At1g09660/At1g09670 {ECO:0000312|Araport:AT1G09660};
GN ORFNames=F21M12.6/F21M12.5 {ECO:0000312|EMBL:AAB60723.1,
GN ECO:0000312|EMBL:AAB60747.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY.
RX PubMed=11809873; DOI=10.1093/nar/30.3.623;
RA Lorkovic Z.J., Barta A.;
RT "Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain
RT RNA-binding proteins from the flowering plant Arabidopsis thaliana.";
RL Nucleic Acids Res. 30:623-635(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GWR3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GWR3-2; Sequence=VSP_036042;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60723.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At1g09660 and At1g09670.; Evidence={ECO:0000305};
CC Sequence=AAB60747.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At1g09660 and At1g09670.; Evidence={ECO:0000305};
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DR EMBL; AC000132; AAB60723.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC000132; AAB60747.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28476.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28477.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58473.1; -; Genomic_DNA.
DR EMBL; AK118683; BAC43277.1; -; mRNA.
DR EMBL; AF419590; AAL31922.1; -; mRNA.
DR EMBL; AY079111; AAL84995.1; -; mRNA.
DR EMBL; BX842524; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK175370; BAD43133.1; -; mRNA.
DR EMBL; AK175796; BAD43559.1; -; mRNA.
DR EMBL; AK176267; BAD44030.1; -; mRNA.
DR EMBL; AK176765; BAD44528.1; -; mRNA.
DR EMBL; AK176899; BAD44662.1; -; mRNA.
DR PIR; D86230; D86230.
DR PIR; E86230; E86230.
DR RefSeq; NP_001320903.1; NM_001331845.1. [Q8GWR3-1]
DR RefSeq; NP_172437.2; NM_100838.6. [Q8GWR3-1]
DR RefSeq; NP_973800.1; NM_202071.3. [Q8GWR3-2]
DR AlphaFoldDB; Q8GWR3; -.
DR SMR; Q8GWR3; -.
DR BioGRID; 22735; 15.
DR IntAct; Q8GWR3; 16.
DR STRING; 3702.AT1G09660.1; -.
DR PaxDb; Q8GWR3; -.
DR PRIDE; Q8GWR3; -.
DR ProteomicsDB; 236616; -. [Q8GWR3-1]
DR EnsemblPlants; AT1G09660.1; AT1G09660.1; AT1G09660. [Q8GWR3-1]
DR EnsemblPlants; AT1G09660.2; AT1G09660.2; AT1G09660. [Q8GWR3-2]
DR EnsemblPlants; AT1G09660.3; AT1G09660.3; AT1G09660. [Q8GWR3-1]
DR GeneID; 837494; -.
DR Gramene; AT1G09660.1; AT1G09660.1; AT1G09660. [Q8GWR3-1]
DR Gramene; AT1G09660.2; AT1G09660.2; AT1G09660. [Q8GWR3-2]
DR Gramene; AT1G09660.3; AT1G09660.3; AT1G09660. [Q8GWR3-1]
DR KEGG; ath:AT1G09660; -.
DR Araport; AT1G09660; -.
DR TAIR; locus:2024326; AT1G09660.
DR eggNOG; KOG1588; Eukaryota.
DR HOGENOM; CLU_065679_0_1_1; -.
DR InParanoid; Q8GWR3; -.
DR OMA; AMTECRI; -.
DR PhylomeDB; Q8GWR3; -.
DR PRO; PR:Q8GWR3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GWR3; baseline and differential.
DR Genevisible; Q8GWR3; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.1370.10; -; 1.
DR InterPro; IPR045071; BBP-like.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR032377; STAR_dimer.
DR PANTHER; PTHR11208; PTHR11208; 1.
DR Pfam; PF16544; STAR_dimer; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW RNA-binding.
FT CHAIN 1..298
FT /note="KH domain-containing protein At1g09660/At1g09670"
FT /id="PRO_0000357032"
FT DOMAIN 152..219
FT /note="KH"
FT REGION 266..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ZVI3"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ZVI3"
FT VAR_SEQ 248..298
FT /note="DESMDHYKREQLKELAALNGTLREESPSPSLSPCLSPSMSPFNSKRAKTEI
FT -> VHSYHKSPNMSILFTWF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14993207"
FT /id="VSP_036042"
FT CONFLICT 32
FT /note="P -> A (in Ref. 5; BX842524)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="P -> A (in Ref. 5; BX842524)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="E -> K (in Ref. 4; AAL31922/AAL84995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 33688 MW; 60AF65D778E5E61C CRC64;
MMESGAGFVA MEERISPGSF FQYPLSGFRA SPNRSPCPPS DRERYLTELL QERQKLGPFL
QVMPNCCRLL NHEIRRVSSF PDLDRYEHGS PFRSLGQPTN GKLDLEGWSM MQAEENCHLQ
RASPFRGPSP VGWIGMPGLP NPPIVKKVIR LDVPVDKYPS YNFVGRILGP RGNSLKRVEL
ATHCRVFIRG RGSVKDTVKE EKLKGKPGYE HLCEPLHVLI EAELPEDIIN SRLEHAVHFL
ESLLKPMDES MDHYKREQLK ELAALNGTLR EESPSPSLSP CLSPSMSPFN SKRAKTEI
