QKY_ARATH
ID QKY_ARATH Reviewed; 1081 AA.
AC B8XCH5; Q0WLK0; Q9CA47; Q9SSF7;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Protein QUIRKY {ECO:0000303|PubMed:19180193};
GN Name=QKY {ECO:0000303|PubMed:19180193};
GN OrderedLocusNames=At1g74720 {ECO:0000312|Araport:AT1G74720};
GN ORFNames=F1M20.40 {ECO:0000312|EMBL:AAG52366.1},
GN F25A4.30 {ECO:0000312|EMBL:AAD55273.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:ACL14176.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=19180193; DOI=10.1371/journal.pgen.1000355;
RA Fulton L., Batoux M., Vaddepalli P., Yadav R.K., Busch W., Andersen S.U.,
RA Jeong S., Lohmann J.U., Schneitz K.;
RT "DETORQUEO, QUIRKY, and ZERZAUST represent novel components involved in
RT organ development mediated by the receptor-like kinase STRUBBELIG in
RT Arabidopsis thaliana.";
RL PLoS Genet. 5:E1000355-E1000355(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1081.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REVIEW.
RX PubMed=20298225; DOI=10.1042/bst0380583;
RA Fulton L., Vaddepalli P., Yadav R.K., Batoux M., Schneitz K.;
RT "Inter-cell-layer signalling during Arabidopsis ovule development mediated
RT by the receptor-like kinase STRUBBELIG.";
RL Biochem. Soc. Trans. 38:583-587(2010).
CC -!- FUNCTION: May be involved in Ca 2(+)-dependent signaling and membrane
CC trafficking. Plays a role in fruit dehiscence (Probable). Components of
CC the machinery involved in organ development mediated by the receptor-
CC like kinase STRUBBELIG (SUB) (PubMed:19180193, PubMed:20298225).
CC {ECO:0000269|PubMed:19180193, ECO:0000303|PubMed:20298225}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000250|UniProtKB:Q6DN14};
CC Note=Binds Ca(2+) via the C2 domains in absence of phospholipids.
CC {ECO:0000250|UniProtKB:Q6DN14};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: STRUBBELIG-like (sub-like) mutant (SLM) phenotype
CC characterized by defects in outer integument development, floral organ
CC shape, and stem twisting, as well as cellular defects in the floral
CC meristem and in root hair patterning. {ECO:0000269|PubMed:19180193}.
CC -!- SIMILARITY: Belongs to the MCTP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD55273.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG52366.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; FJ209045; ACL14176.1; -; mRNA.
DR EMBL; AC008263; AAD55273.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC011765; AAG52366.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35626.1; -; Genomic_DNA.
DR EMBL; AK230199; BAF02007.1; -; mRNA.
DR PIR; E96776; E96776.
DR RefSeq; NP_177610.1; NM_106130.7.
DR AlphaFoldDB; B8XCH5; -.
DR SMR; B8XCH5; -.
DR STRING; 3702.AT1G74720.1; -.
DR TCDB; 9.A.57.1.7; the extended-synaptotagmin (e-syt) family.
DR iPTMnet; B8XCH5; -.
DR PaxDb; B8XCH5; -.
DR PRIDE; B8XCH5; -.
DR ProteomicsDB; 225956; -.
DR EnsemblPlants; AT1G74720.1; AT1G74720.1; AT1G74720.
DR GeneID; 843811; -.
DR Gramene; AT1G74720.1; AT1G74720.1; AT1G74720.
DR KEGG; ath:AT1G74720; -.
DR Araport; AT1G74720; -.
DR TAIR; locus:2019070; AT1G74720.
DR eggNOG; ENOG502QUYP; Eukaryota.
DR HOGENOM; CLU_003762_1_0_1; -.
DR InParanoid; B8XCH5; -.
DR OMA; MQYLFIR; -.
DR OrthoDB; 234298at2759; -.
DR PhylomeDB; B8XCH5; -.
DR PRO; PR:B8XCH5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B8XCH5; baseline and differential.
DR Genevisible; B8XCH5; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0099402; P:plant organ development; IMP:TAIR.
DR GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
DR Gene3D; 2.60.40.150; -; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR013583; PRibTrfase_C.
DR Pfam; PF00168; C2; 4.
DR Pfam; PF08372; PRT_C; 1.
DR SMART; SM00239; C2; 4.
DR SUPFAM; SSF49562; SSF49562; 4.
DR PROSITE; PS50004; C2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Developmental protein; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1081
FT /note="Protein QUIRKY"
FT /id="PRO_0000432550"
FT TRANSMEM 879..899
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 916..936
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 1024..1044
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT DOMAIN 1..124
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 318..440
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 477..605
FT /note="C2 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 652..778
FT /note="C2 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 154..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 652
FT /note="V -> E (in Ref. 4; BAF02007)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1081 AA; 121413 MW; 6263F1508FA7E293 CRC64;
MNTTPFHSDP PPSRIQRKLV VEVVEARNIL PKDGQGSSSA YVVVDFDAQK KRTSTKFRDL
NPIWNEMLDF AVSDPKNMDY DELDIEVYND KRFGNGGGRK NHFLGRVKIY GSQFSRRGEE
GLVYFPLEKK SVFSWIRGEI GLKIYYYDEA ADEDTAGGGG GQQQQQQQQQ FHPPQQEADE
QQHQQQFHPP PQQMMNIPPE KPNVVVVEEG RVFESAQSQR YTETHQQPPV VIVEESPPQH
VMQGPNDNHP HRNDNHPQRP PSPPPPPSAG EVHYYPPEVR KMQVGRPPGG DRIRVTKRPP
NGDYSPRVIN SKTGGGETTM EKKTHHPYNL VEPMQYLFVR IVKARGLPPN ESAYVKVRTS
NHFVRSKPAV NRPGESVDSP EWNQVFALGH NRSDSAVTGA TLEISAWDAS SESFLGGVCF
DLSEVPVRDP PDSPLAPQWY RLEGSGADQN SGRISGDIQL SVWIGTQVDE AFPEAWSSDA
PHVAHTRSKV YQSPKLWYLR VTVLEAQDLH IAPNLPPLTA PEIRVKAQLG FQSARTRRGS
MNNHSGSFHW HEDMIFVAGE PLEDCLVLMV EDRTTKEATL LGHAMIPVSS IEQRIDERFV
PSKWHTLEGE GGGGGGGGGP GGGGGGGPYC GRISLRLCLE GGYHVLEEAA HVCSDFRPTA
KQLWKPPIGI LELGILGARG LLPMKAKNGG KGSTDAYCVA KYGKKWVRTR TITDSFDPRW
HEQYTWQVYD PCTVLTVGVF DNWRMFSDAS DDRPDTRIGK IRIRVSTLES NKVYTNSYPL
LVLLPSGMKK MGEIEVAVRF ACPSLLPDVC AAYGQPLLPR MHYIRPLGVA QQDALRGAAT
KMVAAWLARA EPPLGPEVVR YMLDADSHAW SMRKSKANWY RIVGVLAWAV GLAKWLDNIR
RWRNPVTTVL VHILYLVLVW YPDLVVPTAF LYVVMIGVWY YRFRPKIPAG MDIRLSQAET
VDPDELDEEF DTIPSSRRPE VIRARYDRLR ILAVRVQTIL GDFAAQGERI QALVSWRDPR
ATKLFIAICL VITIVLYAVP AKMVAVALGF YYLRHPMFRD TMPTASLNFF RRLPSLSDRL
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