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QORL1_HUMAN
ID   QORL1_HUMAN             Reviewed;         349 AA.
AC   O95825; B2RDX1; B3KQ77; Q96DY0; Q9NVY7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 186.
DE   RecName: Full=Quinone oxidoreductase-like protein 1;
DE            EC=1.-.-.-;
DE   AltName: Full=Protein 4P11;
DE   AltName: Full=Quinone oxidoreductase homolog 1;
DE            Short=QOH-1;
DE   AltName: Full=Zeta-crystallin homolog;
GN   Name=CRYZL1; Synonyms=4P11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.;
RT   "Identification of a novel gene, 4P11, which maps to the D142H8 region of
RT   chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-2 (AF-1)
RT   gene.";
RL   Eur. Cytokine Netw. 9:504-504(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=10191096; DOI=10.1006/geno.1998.5714;
RA   Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.;
RT   "Identification of a zeta-crystallin (quinone reductase)-like 1 gene
RT   (CRYZL1) mapped to human chromosome 21q22.1.";
RL   Genomics 57:156-159(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis, and Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Eye, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95825-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95825-2; Sequence=VSP_055792, VSP_055793;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH13155.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
CC       Sequence=BAA91605.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF098798; AAD20219.1; -; mRNA.
DR   EMBL; AF029689; AAD22381.1; -; mRNA.
DR   EMBL; AK001293; BAA91605.1; ALT_FRAME; mRNA.
DR   EMBL; AK057604; BAG51939.1; -; mRNA.
DR   EMBL; AK315707; BAG38068.1; -; mRNA.
DR   EMBL; AP000304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC013155; AAH13155.1; ALT_SEQ; mRNA.
DR   EMBL; BC033023; AAH33023.1; -; mRNA.
DR   CCDS; CCDS13633.2; -. [O95825-1]
DR   RefSeq; NP_665857.2; NM_145858.2. [O95825-1]
DR   PDB; 7ND2; EM; 4.00 A; C/D=2-349.
DR   PDBsum; 7ND2; -.
DR   AlphaFoldDB; O95825; -.
DR   SMR; O95825; -.
DR   BioGRID; 115271; 26.
DR   DIP; DIP-62115N; -.
DR   IntAct; O95825; 12.
DR   STRING; 9606.ENSP00000370966; -.
DR   iPTMnet; O95825; -.
DR   MetOSite; O95825; -.
DR   PhosphoSitePlus; O95825; -.
DR   BioMuta; CRYZL1; -.
DR   EPD; O95825; -.
DR   jPOST; O95825; -.
DR   MassIVE; O95825; -.
DR   MaxQB; O95825; -.
DR   PaxDb; O95825; -.
DR   PeptideAtlas; O95825; -.
DR   PRIDE; O95825; -.
DR   ProteomicsDB; 3551; -.
DR   ProteomicsDB; 51072; -. [O95825-1]
DR   Antibodypedia; 7498; 280 antibodies from 23 providers.
DR   DNASU; 9946; -.
DR   Ensembl; ENST00000381554.8; ENSP00000370966.3; ENSG00000205758.12. [O95825-1]
DR   Ensembl; ENST00000420072.5; ENSP00000416315.1; ENSG00000205758.12. [O95825-2]
DR   GeneID; 9946; -.
DR   KEGG; hsa:9946; -.
DR   MANE-Select; ENST00000381554.8; ENSP00000370966.3; NM_145858.3; NP_665857.2.
DR   UCSC; uc002yss.2; human. [O95825-1]
DR   CTD; 9946; -.
DR   DisGeNET; 9946; -.
DR   GeneCards; CRYZL1; -.
DR   HGNC; HGNC:2420; CRYZL1.
DR   HPA; ENSG00000205758; Low tissue specificity.
DR   MIM; 603920; gene.
DR   neXtProt; NX_O95825; -.
DR   OpenTargets; ENSG00000205758; -.
DR   PharmGKB; PA26926; -.
DR   VEuPathDB; HostDB:ENSG00000205758; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   GeneTree; ENSGT00390000013113; -.
DR   InParanoid; O95825; -.
DR   OMA; PHKHDVI; -.
DR   OrthoDB; 1096726at2759; -.
DR   PhylomeDB; O95825; -.
DR   TreeFam; TF328922; -.
DR   PathwayCommons; O95825; -.
DR   SignaLink; O95825; -.
DR   BioGRID-ORCS; 9946; 19 hits in 1078 CRISPR screens.
DR   ChiTaRS; CRYZL1; human.
DR   GeneWiki; CRYZL1; -.
DR   GenomeRNAi; 9946; -.
DR   Pharos; O95825; Tbio.
DR   PRO; PR:O95825; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; O95825; protein.
DR   Bgee; ENSG00000205758; Expressed in cortical plate and 201 other tissues.
DR   ExpressionAtlas; O95825; baseline and differential.
DR   Genevisible; O95825; HS.
DR   GO; GO:0005829; C:cytosol; HDA:UniProtKB.
DR   GO; GO:0050661; F:NADP binding; NAS:UniProtKB.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; NAS:UniProtKB.
DR   GO; GO:1901661; P:quinone metabolic process; NAS:UniProtKB.
DR   InterPro; IPR042633; CRYZL1.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR44461; PTHR44461; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; NADP; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..349
FT                   /note="Quinone oxidoreductase-like protein 1"
FT                   /id="PRO_0000160913"
FT   VAR_SEQ         193..198
FT                   /note="ARVIDV -> ENSTIA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055792"
FT   VAR_SEQ         199..349
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055793"
FT   VARIANT         39
FT                   /note="A -> T (in dbSNP:rs13050238)"
FT                   /id="VAR_027835"
FT   CONFLICT        78
FT                   /note="S -> P (in Ref. 3; BAA91605)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        89
FT                   /note="I -> T (in Ref. 3; BAA91605)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="F -> L (in Ref. 1; AAD20219, 2; AAD22381 and 4;
FT                   AAH13155)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        299
FT                   /note="K -> E (in Ref. 3; BAA91605)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   349 AA;  38697 MW;  7EC26B8852A5BD31 CRC64;
     MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF
     PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT
     EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE
     DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ
     LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
     LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
 
 
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