ID   QORL1_MOUSE             Reviewed;         348 AA.
AC   Q921W4; Q3UKX2; Q8VCS1; Q9CWR9;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Quinone oxidoreductase-like protein 1;
DE            EC=1.-.-.-;
DE   AltName: Full=Quinone oxidoreductase homolog 1;
DE            Short=QOH-1;
DE   AltName: Full=Zeta-crystallin homolog;
GN   Name=Cryzl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Mammary tumor, and Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q921W4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q921W4-2; Sequence=VSP_000209, VSP_000210;
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK010433; BAB26935.1; -; mRNA.
DR   EMBL; AK145827; BAE26679.1; -; mRNA.
DR   EMBL; BC010479; AAH10479.1; -; mRNA.
DR   EMBL; BC019387; AAH19387.1; -; mRNA.
DR   CCDS; CCDS37401.1; -. [Q921W4-1]
DR   RefSeq; NP_598440.1; NM_133679.2. [Q921W4-1]
DR   AlphaFoldDB; Q921W4; -.
DR   SMR; Q921W4; -.
DR   BioGRID; 211592; 1.
DR   STRING; 10090.ENSMUSP00000073171; -.
DR   PhosphoSitePlus; Q921W4; -.
DR   EPD; Q921W4; -.
DR   MaxQB; Q921W4; -.
DR   PaxDb; Q921W4; -.
DR   PeptideAtlas; Q921W4; -.
DR   PRIDE; Q921W4; -.
DR   ProteomicsDB; 301904; -. [Q921W4-1]
DR   ProteomicsDB; 301905; -. [Q921W4-2]
DR   Antibodypedia; 7498; 280 antibodies from 23 providers.
DR   DNASU; 66609; -.
DR   Ensembl; ENSMUST00000073466; ENSMUSP00000073171; ENSMUSG00000058240. [Q921W4-1]
DR   Ensembl; ENSMUST00000114023; ENSMUSP00000109656; ENSMUSG00000058240. [Q921W4-2]
DR   GeneID; 66609; -.
DR   KEGG; mmu:66609; -.
DR   UCSC; uc007zyf.2; mouse. [Q921W4-1]
DR   CTD; 9946; -.
DR   MGI; MGI:1913859; Cryzl1.
DR   VEuPathDB; HostDB:ENSMUSG00000058240; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   GeneTree; ENSGT00390000013113; -.
DR   HOGENOM; CLU_026673_21_5_1; -.
DR   InParanoid; Q921W4; -.
DR   OMA; PHKHDVI; -.
DR   OrthoDB; 1096726at2759; -.
DR   PhylomeDB; Q921W4; -.
DR   TreeFam; TF328922; -.
DR   BioGRID-ORCS; 66609; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Cryzl1; mouse.
DR   PRO; PR:Q921W4; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q921W4; protein.
DR   Bgee; ENSMUSG00000058240; Expressed in sciatic nerve and 266 other tissues.
DR   ExpressionAtlas; Q921W4; baseline and differential.
DR   Genevisible; Q921W4; MM.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR042633; CRYZL1.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR44461; PTHR44461; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Quinone oxidoreductase-like protein 1"
FT                   /id="PRO_0000160914"
FT   VAR_SEQ         226..231
FT                   /note="VRLYSK -> GLEADV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_000209"
FT   VAR_SEQ         232..348
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_000210"
FT   CONFLICT        154..155
FT                   /note="Missing (in Ref. 2; AAH19387)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   348 AA;  38725 MW;  0EED796E6AF7CB42 CRC64;
     MKGLYFQQSS TNEEVTFVFQ EKENVPVTED NFVRVQVKAC ALSHINTKLL AEMKMEKDFF
     PVGREVSGIV LEVGRKVTFF QPDDEVVGIL PLDSEDPGLC EVIRVHEHYL VHKPEKVSWT
     EAAGVIRDGV RACTALYYLS QLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTAHSLE
     DKQHLERLRP SIARVIDVSN GKVHVAESCL EETGGLGVDI VIDAGVRLYS KDDEPAVKLH
     LPHKHDIITL LGVGGHWVTT EENLQLDPPD SHCLFLKGAT VAFLNDEVWN LSNAQQGKYL
     CILKDVMEKL SAGVFRPLLD EPIPLYEAKV SMEVVQKNQE RKKQVVQF