QORL2_MOUSE
ID QORL2_MOUSE Reviewed; 350 AA.
AC Q3UNZ8; Q3UAM2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Quinone oxidoreductase-like protein 2;
DE EC=1.-.-.-;
DE AltName: Full=Zeta-crystallin homolog 2 {ECO:0000312|MGI:MGI:2448516};
GN Name=Cryzl2 {ECO:0000312|MGI:MGI:2448516};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-201, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36; LYS-302 AND LYS-328, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UNZ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UNZ8-2; Sequence=VSP_034229, VSP_034230;
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR EMBL; AK143913; BAE25599.1; -; mRNA.
DR EMBL; AK151310; BAE30292.1; -; mRNA.
DR EMBL; BC045198; AAH45198.1; -; mRNA.
DR CCDS; CCDS15399.1; -. [Q3UNZ8-1]
DR CCDS; CCDS87899.1; -. [Q3UNZ8-2]
DR RefSeq; NP_001028456.1; NM_001033284.1. [Q3UNZ8-1]
DR RefSeq; XP_017175484.1; XM_017319995.1. [Q3UNZ8-1]
DR AlphaFoldDB; Q3UNZ8; -.
DR SMR; Q3UNZ8; -.
DR STRING; 10090.ENSMUSP00000044945; -.
DR GlyConnect; 2663; 2 N-Linked glycans (1 site).
DR iPTMnet; Q3UNZ8; -.
DR PhosphoSitePlus; Q3UNZ8; -.
DR SwissPalm; Q3UNZ8; -.
DR EPD; Q3UNZ8; -.
DR jPOST; Q3UNZ8; -.
DR MaxQB; Q3UNZ8; -.
DR PaxDb; Q3UNZ8; -.
DR PeptideAtlas; Q3UNZ8; -.
DR PRIDE; Q3UNZ8; -.
DR Ensembl; ENSMUST00000046743; ENSMUSP00000044945; ENSMUSG00000033488. [Q3UNZ8-1]
DR Ensembl; ENSMUST00000119891; ENSMUSP00000113664; ENSMUSG00000033488. [Q3UNZ8-2]
DR GeneID; 226527; -.
DR KEGG; mmu:226527; -.
DR UCSC; uc007ddj.1; mouse. [Q3UNZ8-1]
DR UCSC; uc007ddk.1; mouse. [Q3UNZ8-2]
DR CTD; 226527; -.
DR MGI; MGI:2448516; Cryzl2.
DR VEuPathDB; HostDB:ENSMUSG00000033488; -.
DR eggNOG; KOG1198; Eukaryota.
DR GeneTree; ENSGT00940000162916; -.
DR HOGENOM; CLU_026673_3_1_1; -.
DR InParanoid; Q3UNZ8; -.
DR OMA; FWGEFAR; -.
DR OrthoDB; 929126at2759; -.
DR PhylomeDB; Q3UNZ8; -.
DR TreeFam; TF314255; -.
DR BioGRID-ORCS; 226527; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Cryzl2; mouse.
DR PRO; PR:Q3UNZ8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3UNZ8; protein.
DR Bgee; ENSMUSG00000033488; Expressed in right kidney and 150 other tissues.
DR ExpressionAtlas; Q3UNZ8; baseline and differential.
DR Genevisible; Q3UNZ8; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; SSF50129; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Oxidoreductase; Reference proteome.
FT CHAIN 1..350
FT /note="Quinone oxidoreductase-like protein 2"
FT /id="PRO_0000341239"
FT MOD_RES 36
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 201
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 302
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 328
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT VAR_SEQ 165..171
FT /note="ETVLVTA -> STMPSFM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034229"
FT VAR_SEQ 172..350
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034230"
SQ SEQUENCE 350 AA; 37809 MW; 1F36FB378727C9F3 CRC64;
MAARLCTRCL PPVWLCRQAW QGQGRHYRAA LCTELKQPLT IQEVAPRPVG PQEVRVDVHF
CGVNFADILA CRGQYQEKPP LPFTPGMEFS GAVLETGTDV STVKKGDRVI GVSSFHAMAE
QCITDQKTLW RIPENVSLQD AAVLPVSYGT AILAVDHRAR IQPGETVLVT AAAGATGLAV
IDVATNVFRA KVIAATGSDE KCKLAVQRGA QFSVNYSQGS LRDAVKKLAG SGGVNVAIDM
VGGDVFLESL RSLAWEGRIV VLGFAGGNIA SVPSNLLLLK NISAMGLYWG RYQHQDFAVF
SKSMSTAMQY CQQGLIHPHT GAVFKLEKIN DAFLHVMQRK STGKVLLSLK
