ID   QOR_LEIAM               Reviewed;         340 AA.
AC   P42865;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
DE   AltName: Full=P36;
OS   Leishmania amazonensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7808470; DOI=10.1016/0166-6851(94)90147-3;
RA   Liu X., Chang K.P.;
RT   "Identification by extrachromosomal amplification and overexpression of a
RT   zeta-crystallin/NADPH-oxidoreductase homologue constitutively expressed in
RT   Leishmania spp.";
RL   Mol. Biochem. Parasitol. 66:201-210(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone +
CC         NADP(+); Xref=Rhea:RHEA:14269, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:132124, ChEBI:CHEBI:134225;
CC         EC=1.6.5.5;
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L11705; AAA73554.1; -; Genomic_DNA.
DR   AlphaFoldDB; P42865; -.
DR   SMR; P42865; -.
DR   VEuPathDB; TriTrypDB:LAMA_000348900; -.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..340
FT                   /note="Probable quinone oxidoreductase"
FT                   /id="PRO_0000160911"
SQ   SEQUENCE   340 AA;  36272 MW;  4D9255AB56856625 CRC64;
     MSSPSNFKKL QVVSLSKDFR SSTSVVEAHL PEEVPEGMVR VSVKYAGVNA SDLNFTNGSY
     FKNVQPPFDC GFEAAGTVVQ IGAGVANVKV GDHVVLMQYG CFAEFLDAPA ERCIPVPELK
     PEYSVLPVSA LTAAVALGEV GRVKKGDVAL VTAAAGGTGQ IAVQLLKHVY GCTVIGTCSS
     EEKAEFLKSI GCDHVINYKT ESLDGRLHEL CPKGVDVVYE CVGGHTFNDA VRHVAVHARV
     VIIGSISSYK SGEVVPFSDP SGTSVTMLLL VKSASLNGFF LPQFHDVIPK YMANLLQYLK
     AGQVKLFVDK KVFHGLSSVA DAVDHLYSGA NYGKVLVEIQ