ID   QOR_SALTY               Reviewed;         327 AA.
AC   P40783;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
DE   AltName: Full=Zeta-crystallin homolog protein;
GN   Name=qor; OrderedLocusNames=STM4245;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-168.
RX   PubMed=2836367; DOI=10.1128/jb.170.6.2668-2675.1988;
RA   Wong A., Kean L., Maurer R.;
RT   "Sequence of the dnaB gene of Salmonella typhimurium.";
RL   J. Bacteriol. 170:2668-2675(1988).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone +
CC         NADP(+); Xref=Rhea:RHEA:14269, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:132124, ChEBI:CHEBI:134225;
CC         EC=1.6.5.5;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR   EMBL; AE006468; AAL23069.1; -; Genomic_DNA.
DR   EMBL; J03390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_463110.1; NC_003197.2.
DR   RefSeq; WP_000235551.1; NC_003197.2.
DR   AlphaFoldDB; P40783; -.
DR   SMR; P40783; -.
DR   STRING; 99287.STM4245; -.
DR   PaxDb; P40783; -.
DR   EnsemblBacteria; AAL23069; AAL23069; STM4245.
DR   GeneID; 1255771; -.
DR   KEGG; stm:STM4245; -.
DR   PATRIC; fig|99287.12.peg.4465; -.
DR   HOGENOM; CLU_026673_3_1_6; -.
DR   OMA; THIATRE; -.
DR   PhylomeDB; P40783; -.
DR   BioCyc; SENT99287:STM4245-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070402; F:NADPH binding; IBA:GO_Central.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; IBA:GO_Central.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..327
FT                   /note="Quinone oxidoreductase"
FT                   /id="PRO_0000160902"
FT   CONFLICT        92
FT                   /note="L -> V (in Ref. 2; J03390)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="A -> R (in Ref. 2; J03390)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   327 AA;  35151 MW;  602F4CB6E6A805F1 CRC64;
     MATRIEFHKH GGPEVLQTVE FTPAEPAEHE IQVENKAIGI NFIDTYIRSG LYPPPSLPAG
     LGTEAAGVVS KVGNGVEHIR VGDRVVYAQS TLGAYSSVHN VTADKAAILP DAISFEQAAA
     SFLKGLTVFY LLRKTYEVKP DEPFLFHAAA GGVGLIACQW AKALGAKLIG TVGSAQKAQR
     ALDAGAWQVI NYREESIVER VKEITGGKKV RVVYDSVGKD TWEASLDCLQ RRGLMVSFGN
     ASGPVTGVNL GILNQKGSLY ATRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAENQ
     RYALKDARRA HEVLESRATQ GSSLLIP