QOX2_BACAN
ID QOX2_BACAN Reviewed; 291 AA.
AC Q81V01; Q6I384; Q6KX02;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Quinol oxidase subunit 2;
DE EC=1.10.3.-;
DE AltName: Full=Cytochrome aa(3) subunit 2;
DE AltName: Full=Quinol oxidase polypeptide II;
DE Flags: Precursor;
GN Name=qoxA {ECO:0000312|EMBL:AAP24716.1};
GN OrderedLocusNames=BA_0703, GBAA_0703, BAS0669;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton {ECO:0000269|PubMed:12721629};
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3] {ECO:0000312|EMBL:AAT29808.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes quinol oxidation with the concomitant reduction of
CC oxygen to water. Subunit II transfers the electrons from a quinol to
CC the binuclear center of the catalytic subunit I (By similarity).
CC {ECO:0000250|UniProtKB:Q81HT3}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 a quinol + O2 = 2 a quinone + 2 H2O; Xref=Rhea:RHEA:55376,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:132124; Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC {ECO:0000255}.
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DR EMBL; AE016879; AAP24716.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT29808.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT52997.1; -; Genomic_DNA.
DR RefSeq; NP_843230.1; NC_003997.3.
DR RefSeq; WP_001176167.1; NZ_QPKQ01000007.1.
DR RefSeq; YP_026946.1; NC_005945.1.
DR AlphaFoldDB; Q81V01; -.
DR SMR; Q81V01; -.
DR STRING; 261594.GBAA_0703; -.
DR DNASU; 1088154; -.
DR EnsemblBacteria; AAP24716; AAP24716; BA_0703.
DR EnsemblBacteria; AAT29808; AAT29808; GBAA_0703.
DR GeneID; 59156481; -.
DR GeneID; 64203839; -.
DR KEGG; ban:BA_0703; -.
DR KEGG; bar:GBAA_0703; -.
DR KEGG; bat:BAS0669; -.
DR PATRIC; fig|198094.11.peg.702; -.
DR eggNOG; COG1622; Bacteria.
DR HOGENOM; CLU_036876_6_0_9; -.
DR OMA; TAMNSFF; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0016682; F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; ISS:UniProtKB.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; ISS:UniProtKB.
DR CDD; cd04212; CuRO_UO_II; 1.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR045187; CcO_II.
DR InterPro; IPR002429; CcO_II-like_C.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR034227; CuRO_UO_II.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf.
DR InterPro; IPR006333; Cyt_o_ubiquinol_oxidase_su2.
DR InterPro; IPR006332; QoxA.
DR PANTHER; PTHR22888; PTHR22888; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR PIRSF; PIRSF000292; Ubi_od_II; 1.
DR SUPFAM; SSF49503; SSF49503; 1.
DR SUPFAM; SSF81464; SSF81464; 1.
DR TIGRFAMs; TIGR01432; QOXA; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Cell membrane; Electron transport; Membrane; Oxidoreductase;
KW Reference proteome; Respiratory chain; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000250|UniProtKB:Q81HT3"
FT CHAIN 29..291
FT /note="Quinol oxidase subunit 2"
FT /id="PRO_0000006066"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 291 AA; 33336 MW; D760A8AEB4B4AD4F CRC64;
MQLKKAFWKL ASLLPLSLLL FLGGCDKKLA VLNPQGPVAK AQYDLIVWSF LLMSLIIAIV
FILFTVILIR YREKPENMDY EPPEQHGNTL LEIIWTLVPV IIVIALSIPT VKATYASEEV
PKESKHIKPV EIYVTSANWK WLFSYPEEKI ETVNYLNIPA GVPIQFKLTS VGPMNAFWVP
ELGGMKYTMD GMIMDLYLQA DKPGSYLGRS ANFSGEGFTH MEFEVEAKTK EKYDKWVKEV
QQTAPKLTED KYNEIVKPGV VGRMTFSSHH LSYVDPKSLE YCDYNYYKNK K
