ID   QOX4_STAA8              Reviewed;          96 AA.
AC   Q2FZK2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable quinol oxidase subunit 4;
DE            EC=1.10.3.-;
DE   AltName: Full=Quinol oxidase polypeptide IV;
GN   Name=qoxD; OrderedLocusNames=SAOUHSC_00999;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Catalyzes quinol oxidation with the concomitant reduction of
CC       oxygen to water. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinol + O2 = 2 a quinone + 2 H2O; Xref=Rhea:RHEA:55376,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:132124;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD30123.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000253; ABD30123.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_499551.1; NC_007795.1.
DR   AlphaFoldDB; Q2FZK2; -.
DR   SMR; Q2FZK2; -.
DR   STRING; 1280.SAXN108_1055; -.
DR   EnsemblBacteria; ABD30123; ABD30123; SAOUHSC_00999.
DR   GeneID; 3920399; -.
DR   KEGG; sao:SAOUHSC_00999; -.
DR   PATRIC; fig|93061.5.peg.917; -.
DR   eggNOG; COG3125; Bacteria.
DR   HOGENOM; CLU_140945_2_0_9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0009319; C:cytochrome o ubiquinol oxidase complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IBA:GO_Central.
DR   GO; GO:0016682; F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0019646; P:aerobic electron transport chain; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR   InterPro; IPR014250; QoxD.
DR   Pfam; PF03626; COX4_pro; 1.
DR   TIGRFAMs; TIGR02901; QoxD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..96
FT                   /note="Probable quinol oxidase subunit 4"
FT                   /id="PRO_0000275864"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  10687 MW;  614E29CDB8BE3EAE CRC64;
     MSTIMKHTVG FIASIVLTLL AVYVTLYTSL TFHAKLTIIF GFAFVQAGLQ LLMFMHLTEG
     KDGRLQTFKV IFALVITLCF VVGTYWVMQG GHSSHL