ID   QOX4_STAAM              Reviewed;          96 AA.
AC   Q99V39;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable quinol oxidase subunit 4;
DE            EC=1.10.3.-;
DE   AltName: Full=Quinol oxidase polypeptide IV;
GN   Name=qoxD; OrderedLocusNames=SAV1058;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Catalyzes quinol oxidation with the concomitant reduction of
CC       oxygen to water. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinol + O2 = 2 a quinone + 2 H2O; Xref=Rhea:RHEA:55376,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:132124;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC       family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB57220.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q99V39; -.
DR   SMR; Q99V39; -.
DR   PaxDb; Q99V39; -.
DR   EnsemblBacteria; BAB57220; BAB57220; SAV1058.
DR   KEGG; sav:SAV1058; -.
DR   HOGENOM; CLU_140945_2_0_9; -.
DR   OMA; AASIWIM; -.
DR   PhylomeDB; Q99V39; -.
DR   BioCyc; SAUR158878:SAV_RS05705-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016682; F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR   InterPro; IPR014250; QoxD.
DR   Pfam; PF03626; COX4_pro; 1.
DR   TIGRFAMs; TIGR02901; QoxD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Oxidoreductase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..96
FT                   /note="Probable quinol oxidase subunit 4"
FT                   /id="PRO_0000275861"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  10687 MW;  614E29CDB8BE3EAE CRC64;
     MSTIMKHTVG FIASIVLTLL AVYVTLYTSL TFHAKLTIIF GFAFVQAGLQ LLMFMHLTEG
     KDGRLQTFKV IFALVITLCF VVGTYWVMQG GHSSHL