ID   QOX4_STAES              Reviewed;          96 AA.
AC   Q8CPP9;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable quinol oxidase subunit 4;
DE            EC=1.10.3.-;
DE   AltName: Full=Quinol oxidase polypeptide IV;
GN   Name=qoxD; OrderedLocusNames=SE_0756;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Catalyzes quinol oxidation with the concomitant reduction of
CC       oxygen to water. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinol + O2 = 2 a quinone + 2 H2O; Xref=Rhea:RHEA:55376,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:132124;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC       family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO04353.1; -; Genomic_DNA.
DR   RefSeq; NP_764311.1; NC_004461.1.
DR   RefSeq; WP_001831700.1; NZ_WBME01000028.1.
DR   AlphaFoldDB; Q8CPP9; -.
DR   SMR; Q8CPP9; -.
DR   STRING; 176280.SE_0756; -.
DR   EnsemblBacteria; AAO04353; AAO04353; SE_0756.
DR   GeneID; 50019104; -.
DR   KEGG; sep:SE_0756; -.
DR   PATRIC; fig|176280.10.peg.728; -.
DR   eggNOG; COG3125; Bacteria.
DR   HOGENOM; CLU_140945_2_0_9; -.
DR   OMA; IVVHMVF; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016682; F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR   InterPro; IPR014250; QoxD.
DR   Pfam; PF03626; COX4_pro; 1.
DR   TIGRFAMs; TIGR02901; QoxD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Oxidoreductase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..96
FT                   /note="Probable quinol oxidase subunit 4"
FT                   /id="PRO_0000275866"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  10689 MW;  07D5F7FA957833E1 CRC64;
     MNTIVKHTVG FIASIVLTLL AVFVTLYTNM TFHAKVTIIF GFAFIQAALQ LLMFMHLTEG
     KDGRLQSFKV IFAIIITLVT VIGTYWVMQG GHSSHL