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QPTR_ECOLI
ID   QPTR_ECOLI              Reviewed;         221 AA.
AC   P37619; Q2M7D4;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Queuosine precursor transporter {ECO:0000305};
DE            Short=Q precursor transporter {ECO:0000255|HAMAP-Rule:MF_02088, ECO:0000305};
GN   Name=yhhQ; OrderedLocusNames=b3471, JW3436;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28208705; DOI=10.3390/biom7010012;
RA   Zallot R., Yuan Y., de Crecy-Lagard V.;
RT   "The Escherichia coli COG1738 member YhhQ is involved in 7-
RT   cyanodeazaguanine (preQ(0)) transport.";
RL   Biomolecules 7:0-0(2017).
CC   -!- FUNCTION: Involved in the import of queuosine (Q) precursors, required
CC       for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ(0))
CC       and 7-aminomethyl-7-deazaguanine (preQ(1)), with a preference for
CC       preQ(0). {ECO:0000269|PubMed:28208705}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02088, ECO:0000269|PubMed:15919996}; Multi-pass membrane
CC       protein {ECO:0000255|HAMAP-Rule:MF_02088}.
CC   -!- DISRUPTION PHENOTYPE: YhhQ-queD double mutant cannot produce Q modified
CC       tRNA in minimal media with preQ(0) or preQ(1). YhhQ expressed from a
CC       plasmid restores the presence of Q modified tRNA.
CC       {ECO:0000269|PubMed:28208705}.
CC   -!- SIMILARITY: Belongs to the vitamin uptake transporter (VUT/ECF) (TC
CC       2.A.88) family. Q precursor transporter subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_02088, ECO:0000305}.
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DR   EMBL; U00039; AAB18446.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76496.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77822.1; -; Genomic_DNA.
DR   PIR; S47690; S47690.
DR   RefSeq; NP_417928.1; NC_000913.3.
DR   RefSeq; WP_001100469.1; NZ_SSZK01000008.1.
DR   AlphaFoldDB; P37619; -.
DR   STRING; 511145.b3471; -.
DR   PaxDb; P37619; -.
DR   PRIDE; P37619; -.
DR   EnsemblBacteria; AAC76496; AAC76496; b3471.
DR   EnsemblBacteria; BAE77822; BAE77822; BAE77822.
DR   GeneID; 947984; -.
DR   KEGG; ecj:JW3436; -.
DR   KEGG; eco:b3471; -.
DR   PATRIC; fig|1411691.4.peg.3254; -.
DR   EchoBASE; EB2131; -.
DR   eggNOG; COG1738; Bacteria.
DR   HOGENOM; CLU_090905_0_0_6; -.
DR   InParanoid; P37619; -.
DR   OMA; IWLSLFH; -.
DR   PhylomeDB; P37619; -.
DR   BioCyc; EcoCyc:EG12217-MON; -.
DR   BioCyc; MetaCyc:EG12217-MON; -.
DR   PRO; PR:P37619; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0072531; P:pyrimidine-containing compound transmembrane transport; IDA:EcoCyc.
DR   GO; GO:1990397; P:queuosine salvage; IDA:EcoCyc.
DR   HAMAP; MF_02088; Q_prec_transport; 1.
DR   InterPro; IPR003744; YhhQ.
DR   PANTHER; PTHR34300; PTHR34300; 1.
DR   Pfam; PF02592; Vut_1; 1.
DR   TIGRFAMs; TIGR00697; TIGR00697; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..221
FT                   /note="Queuosine precursor transporter"
FT                   /id="PRO_0000169556"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        34
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        56..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        92..97
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        119..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        165..184
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02088"
FT   TOPO_DOM        206..221
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:15919996"
SQ   SEQUENCE   221 AA;  25269 MW;  E3D90237BEE7ABCC CRC64;
     MNVFSQTQRY KALFWLSLFH LLVITSSNYL VQLPVSILGF HTTWGAFSFP FIFLATDLTV
     RIFGAPLARR IIFAVMIPAL LISYVISSLF YMGSWQGFGA LAHFNLFVAR IATASFMAYA
     LGQILDVHVF NRLRQSRRWW LAPTASTLFG NVSDTLAFFF IAFWRSPDAF MAEHWMEIAL
     VDYCFKVLIS IVFFLPMYGV LLNMLLKRLA DKSEINALQA S
 
 
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