QRFPR_HUMAN
ID QRFPR_HUMAN Reviewed; 431 AA.
AC Q96P65;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Pyroglutamylated RF-amide peptide receptor;
DE AltName: Full=AQ27;
DE AltName: Full=G-protein coupled receptor 103;
DE AltName: Full=Orexigenic neuropeptide QRFP receptor;
DE AltName: Full=SP9155;
GN Name=QRFPR; Synonyms=GPR103;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL Gene 275:83-91(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12714592; DOI=10.1074/jbc.m302945200;
RA Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N.,
RA Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S.,
RA Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.;
RT "Identification and characterization of a novel RF-amide peptide ligand for
RT orphan G-protein-coupled receptor SP9155.";
RL J. Biol. Chem. 278:27652-27657(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Fetal brain;
RX PubMed=12960173; DOI=10.1074/jbc.m305270200;
RA Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA Shintani Y., Hinuma S., Fujino M.;
RT "A new peptidic ligand and its receptor regulating adrenal function in
RT rats.";
RL J. Biol. Chem. 278:46387-46395(2003).
CC -!- FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The activity
CC of this receptor is mediated by G proteins that modulate adenylate
CC cyclase activity and intracellular calcium levels.
CC {ECO:0000269|PubMed:12960173}.
CC -!- INTERACTION:
CC Q96P65; P48165: GJA8; NbExp=3; IntAct=EBI-12820497, EBI-17458373;
CC Q96P65; Q9P121-3: NTM; NbExp=3; IntAct=EBI-12820497, EBI-12027160;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed widely in the brain with high levels in
CC the hypothalamus, trigeminal ganglia and vestibular neurons, and
CC moderate levels in the amygdala, cortex, pituitary, hippocampus,
CC thalamus, caudate nucleus and medulla oblongata. In peripheral tissues,
CC expressed at high levels in the retina and at moderate levels in the
CC heart, kidney, testis and thyroid. {ECO:0000269|PubMed:11574155,
CC ECO:0000269|PubMed:12714592}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF411117; AAL26488.1; ALT_INIT; mRNA.
DR EMBL; AB109629; BAC98938.1; -; mRNA.
DR CCDS; CCDS3719.1; -.
DR RefSeq; NP_937822.2; NM_198179.2.
DR AlphaFoldDB; Q96P65; -.
DR SMR; Q96P65; -.
DR BioGRID; 123897; 3.
DR IntAct; Q96P65; 2.
DR STRING; 9606.ENSP00000377948; -.
DR BindingDB; Q96P65; -.
DR ChEMBL; CHEMBL5852; -.
DR GuidetoPHARMACOLOGY; 333; -.
DR GlyGen; Q96P65; 1 site.
DR iPTMnet; Q96P65; -.
DR PhosphoSitePlus; Q96P65; -.
DR BioMuta; QRFPR; -.
DR DMDM; 47117904; -.
DR MassIVE; Q96P65; -.
DR PaxDb; Q96P65; -.
DR PeptideAtlas; Q96P65; -.
DR PRIDE; Q96P65; -.
DR ProteomicsDB; 77639; -.
DR Antibodypedia; 2965; 280 antibodies from 31 providers.
DR DNASU; 84109; -.
DR Ensembl; ENST00000394427.3; ENSP00000377948.2; ENSG00000186867.11.
DR GeneID; 84109; -.
DR KEGG; hsa:84109; -.
DR MANE-Select; ENST00000394427.3; ENSP00000377948.2; NM_198179.3; NP_937822.2.
DR UCSC; uc010inj.2; human.
DR CTD; 84109; -.
DR DisGeNET; 84109; -.
DR GeneCards; QRFPR; -.
DR HGNC; HGNC:15565; QRFPR.
DR HPA; ENSG00000186867; Group enriched (brain, heart muscle, kidney).
DR MIM; 606925; gene.
DR neXtProt; NX_Q96P65; -.
DR OpenTargets; ENSG00000186867; -.
DR PharmGKB; PA164725243; -.
DR VEuPathDB; HostDB:ENSG00000186867; -.
DR eggNOG; ENOG502QW2F; Eukaryota.
DR GeneTree; ENSGT01050000244933; -.
DR InParanoid; Q96P65; -.
DR OMA; KRAIVMM; -.
DR OrthoDB; 1485786at2759; -.
DR PhylomeDB; Q96P65; -.
DR TreeFam; TF315303; -.
DR PathwayCommons; Q96P65; -.
DR Reactome; R-HSA-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; Q96P65; -.
DR BioGRID-ORCS; 84109; 13 hits in 1065 CRISPR screens.
DR ChiTaRS; QRFPR; human.
DR GeneWiki; Pyroglutamylated_RFamide_peptide_receptor; -.
DR GenomeRNAi; 84109; -.
DR Pharos; Q96P65; Tchem.
DR PRO; PR:Q96P65; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96P65; protein.
DR Bgee; ENSG00000186867; Expressed in cortex of kidney and 75 other tissues.
DR ExpressionAtlas; Q96P65; baseline and differential.
DR Genevisible; Q96P65; HS.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..431
FT /note="Pyroglutamylated RF-amide peptide receptor"
FT /id="PRO_0000070097"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..431
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 61
FT /note="F -> V (in dbSNP:rs17438900)"
FT /id="VAR_049437"
FT VARIANT 149
FT /note="H -> Q (in dbSNP:rs11947418)"
FT /id="VAR_049438"
FT VARIANT 344
FT /note="L -> S (in dbSNP:rs2302310)"
FT /id="VAR_049439"
FT CONFLICT 28..29
FT /note="LY -> VH (in Ref. 3; BAC98938)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..266
FT /note="VILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIAR -> S
FT SSSSCLLW (in Ref. 1; AAL26488)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 49488 MW; 778D9AE70528024D CRC64;
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL
FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM
VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM
WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE
LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ
RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE
LAENSPLDSG H
