QRFP_BRAFL
ID QRFP_BRAFL Reviewed; 131 AA.
AC C3Z6E6;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=QRFP-like peptide {ECO:0000303|PubMed:25449662};
DE Flags: Precursor;
GN Name=QRFP {ECO:0000303|PubMed:25449662};
GN ORFNames=BRAFLDRAFT_107075 {ECO:0000312|EMBL:EEN51890.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000312|Proteomes:UP000001554};
RN [1] {ECO:0000312|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000312|Proteomes:UP000001554};
RX PubMed=18563158; DOI=10.1038/nature06967;
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000305}
RP SYNTHESIS OF 95-119, FUNCTION, SUBCELLULAR LOCATION, AND AMIDATION AT
RP PHE-119.
RX PubMed=25449662; DOI=10.1016/j.ygcen.2014.10.010;
RA Xu B., Bergqvist C.A., Sundstroem G., Lundell I., Vaudry H., Leprince J.,
RA Larhammar D.;
RT "Characterization of peptide QRFP (26RFa) and its receptor from amphioxus,
RT Branchiostoma floridae.";
RL Gen. Comp. Endocrinol. 210:107-113(2015).
CC -!- FUNCTION: Ligand for the G-protein coupled receptor QRFPR.
CC {ECO:0000269|PubMed:25449662}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25449662}.
CC -!- SIMILARITY: Belongs to the RFamide neuropeptide family. {ECO:0000305}.
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DR EMBL; GG666587; EEN51890.1; -; Genomic_DNA.
DR RefSeq; XP_002595878.1; XM_002595832.1.
DR AlphaFoldDB; C3Z6E6; -.
DR OrthoDB; 1571514at2759; -.
DR Proteomes; UP000001554; Partially assembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IC:UniProtKB.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:UniProtKB.
DR GO; GO:0031854; F:orexigenic neuropeptide QRFP receptor binding; IEA:InterPro.
DR InterPro; IPR024565; P518.
DR Pfam; PF11109; RFamide_26RFa; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..94
FT /evidence="ECO:0000305"
FT /id="PRO_0000442015"
FT PEPTIDE 95..119
FT /note="QRFP-like peptide"
FT /evidence="ECO:0000305|PubMed:25449662"
FT /id="PRO_0000442016"
FT PROPEP 123..131
FT /evidence="ECO:0000305"
FT /id="PRO_0000442017"
FT REGION 48..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000305|PubMed:25449662"
SQ SEQUENCE 131 AA; 14750 MW; B22B82DD94DEDC45 CRC64;
MGVRVMRSRI CVIGLLVLML TQSEAYSFRE KSWRTSPYYR QYGGYFRRRD GGDQAPSFTS
TGNGEDVSNG LDDDAGIYLS DQAGDDGISP ADKRSAMLQQ LAQQLKNRPR EKGGFTFRFG
KRESRRSFGS D
