ID   QSEB_ECO57              Reviewed;         219 AA.
AC   Q8XBS3;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Transcriptional regulatory protein QseB;
GN   Name=qseB; OrderedLocusNames=Z4377, ECs3907;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   FUNCTION.
RC   STRAIN=K12, and O157:H7 / EHEC;
RX   PubMed=11929534; DOI=10.1046/j.1365-2958.2002.02803.x;
RA   Sperandio V., Torres A.G., Kaper J.B.;
RT   "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-
RT   component regulatory system involved in the regulation of flagella and
RT   motility by quorum sensing in E. coli.";
RL   Mol. Microbiol. 43:809-821(2002).
CC   -!- FUNCTION: Member of a two-component regulatory system QseB/QseC.
CC       Activates the flagella regulon by activating transcription of FlhDC.
CC       Currently it is not known whether this effect is direct or not.
CC       {ECO:0000269|PubMed:11929534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By the AI-2 quorum sensing system.
CC   -!- PTM: Phosphorylated by QseC. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; AAG58159.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37330.1; -; Genomic_DNA.
DR   PIR; C85962; C85962.
DR   PIR; C91117; C91117.
DR   RefSeq; NP_311934.1; NC_002695.1.
DR   RefSeq; WP_001221502.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XBS3; -.
DR   SMR; Q8XBS3; -.
DR   STRING; 155864.EDL933_4246; -.
DR   EnsemblBacteria; AAG58159; AAG58159; Z4377.
DR   EnsemblBacteria; BAB37330; BAB37330; ECs_3907.
DR   GeneID; 66673084; -.
DR   GeneID; 916262; -.
DR   KEGG; ece:Z4377; -.
DR   KEGG; ecs:ECs_3907; -.
DR   PATRIC; fig|386585.9.peg.4075; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   OMA; SYPRRVW; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..219
FT                   /note="Transcriptional regulatory protein QseB"
FT                   /id="PRO_0000081026"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..218
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   219 AA;  24746 MW;  911EF9DA979A07FA CRC64;
     MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL DLTLPGMDGR
     DILREWREKG QREPVLILTA RDALEERVEG LRLGADDYLC KPFALIEVAA RLEALMRRTN
     GQASNELRHG NVMLDPGKRI ATLAGEPLTL KPKEFALLEL LMRNAGRVLP RKLIEEKLYT
     WDEEVTSNAV EVHVHHLRRK LGSDFIRTVH GIGYTLGEK