QSEB_ECOLI
ID QSEB_ECOLI Reviewed; 219 AA.
AC P52076; Q2M9H5;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Transcriptional regulatory protein QseB;
GN Name=qseB; Synonyms=ygiX; OrderedLocusNames=b3025, JW2993;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP FUNCTION.
RC STRAIN=K12, and O157:H7;
RX PubMed=11929534; DOI=10.1046/j.1365-2958.2002.02803.x;
RA Sperandio V., Torres A.G., Kaper J.B.;
RT "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-
RT component regulatory system involved in the regulation of flagella and
RT motility by quorum sensing in E. coli.";
RL Mol. Microbiol. 43:809-821(2002).
RN [4]
RP INDUCTION BY AI-2 AND MQSR.
RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha, and
RC K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16352847; DOI=10.1128/jb.188.1.305-316.2006;
RA Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E.,
RA Wood T.K.;
RT "Autoinducer 2 controls biofilm formation in Escherichia coli through a
RT novel motility quorum-sensing regulator (MqsR, B3022).";
RL J. Bacteriol. 188:305-316(2006).
CC -!- FUNCTION: Member of a two-component regulatory system QseB/QseC.
CC Activates the flagella regulon by activating transcription of FlhDC.
CC Currently it is not known whether this effect is direct or not.
CC {ECO:0000269|PubMed:11929534}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- INDUCTION: By the signal autoinducer AI-2, through MqsR.
CC {ECO:0000269|PubMed:16352847}.
CC -!- PTM: Phosphorylated by QseC. {ECO:0000305}.
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DR EMBL; U28377; AAA69193.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76061.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77081.1; -; Genomic_DNA.
DR PIR; G65089; G65089.
DR RefSeq; NP_417497.1; NC_000913.3.
DR RefSeq; WP_001221495.1; NZ_LN832404.1.
DR AlphaFoldDB; P52076; -.
DR SMR; P52076; -.
DR BioGRID; 4262391; 17.
DR IntAct; P52076; 5.
DR STRING; 511145.b3025; -.
DR jPOST; P52076; -.
DR PaxDb; P52076; -.
DR PRIDE; P52076; -.
DR EnsemblBacteria; AAC76061; AAC76061; b3025.
DR EnsemblBacteria; BAE77081; BAE77081; BAE77081.
DR GeneID; 945369; -.
DR KEGG; ecj:JW2993; -.
DR KEGG; eco:b3025; -.
DR PATRIC; fig|1411691.4.peg.3705; -.
DR EchoBASE; EB2844; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_1_6; -.
DR InParanoid; P52076; -.
DR OMA; SYPRRVW; -.
DR PhylomeDB; P52076; -.
DR BioCyc; EcoCyc:G7575-MON; -.
DR PRO; PR:P52076; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0010038; P:response to metal ion; IMP:EcoCyc.
DR GO; GO:0006351; P:transcription, DNA-templated; EXP:EcoCyc.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..219
FT /note="Transcriptional regulatory protein QseB"
FT /id="PRO_0000081025"
FT DOMAIN 2..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 124..218
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 51
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 219 AA; 24678 MW; 9408B2B7261E042E CRC64;
MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL DLTLPGMDGR
DILREWREKG QREPVLILTA RDALAERVEG LRLGADDYLC KPFALIEVAA RLEALMRRTN
GQASNELRHG NVMLDPGKRI ATLAGEPLTL KPKEFALLEL LMRNAGRVLS RKLIEEKLYT
WDEEVTSNAV EVHVHHLRRK LGSDFIRTVH GIGYTLGEK
