ID   QSEC_HAEIN              Reviewed;         451 AA.
AC   P45336;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Sensor protein QseC;
DE            EC=2.7.13.3;
GN   Name=qseC; OrderedLocusNames=HI_1707;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Member of a two-component regulatory system QseB/QseC. May
CC       activate QseB by phosphorylation (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; L42023; AAC23353.1; -; Genomic_DNA.
DR   PIR; E64137; E64137.
DR   RefSeq; NP_439849.1; NC_000907.1.
DR   RefSeq; WP_005694197.1; NC_000907.1.
DR   AlphaFoldDB; P45336; -.
DR   SMR; P45336; -.
DR   STRING; 71421.HI_1707; -.
DR   EnsemblBacteria; AAC23353; AAC23353; HI_1707.
DR   KEGG; hin:HI_1707; -.
DR   PATRIC; fig|71421.8.peg.1786; -.
DR   eggNOG; COG0642; Bacteria.
DR   HOGENOM; CLU_000445_89_37_6; -.
DR   OMA; DKLFDTQ; -.
DR   PhylomeDB; P45336; -.
DR   BioCyc; HINF71421:G1GJ1-1723-MON; -.
DR   BRENDA; 2.7.13.3; 2529.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IBA:GO_Central.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR013727; 2CSK_N.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF08521; 2CSK_N; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..451
FT                   /note="Sensor protein QseC"
FT                   /id="PRO_0000074705"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..162
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..451
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          181..233
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          241..451
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         244
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   451 AA;  51271 MW;  00C86B648128D383 CRC64;
     MKNRSLTLRL ISVLCLTALF VWLGSTLVAW WQVRHDVNKV FDAQQVLFAE RLANSDLSTI
     LLESSTTLNK NSQSVLKKSY DDDALAFAIF SKTGKLLFSD GRNGKDFIFN YKTGFYNANI
     YDDDDKWRIF WRMAANGELV IAVGQELDYR EDLIEEMILG QMWIWFASLP ILIIVLGWLI
     HKELRPIKRL SQEVQTRKSG DVSLLNTEGL PVEILPLVKN LNQFFDRTSA MLQRERRFTS
     DAAHELRSPL AALRIQIEVA QLAGDDVALR EQALLHLTQG IDRASQLIEQ LLTLSRLDNL
     QALETLQLLD WEAIVQSLIS ERYFVAEKRK ITLVFEKESE PKQKQGQSIL VSLMLRNLLD
     NAIKYCPEDT IVSVKISSSQ IIIEDNGGGV EPEDLKKLGQ RFYRPAGQNE KGSGLGLSIV
     MRIAELHGFK VRLENVVKEG RRIGLKAIIS L