ID   QSED_ECO57              Reviewed;         242 AA.
AC   Q8X487;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=HTH domain-truncated transcriptional regulator QseD;
DE   AltName: Full=Quorum-sensing regulator protein D;
GN   Name=qseD; OrderedLocusNames=Z5926;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   FUNCTION AS A REPRESSOR, AND INDUCTION.
RC   STRAIN=O157:H7 / 86-24 / EHEC;
RX   PubMed=20494990; DOI=10.1128/jb.00382-10;
RA   Habdas B.J., Smart J., Kaper J.B., Sperandio V.;
RT   "The LysR-type transcriptional regulator QseD alters type three secretion
RT   in enterohemorrhagic Escherichia coli and motility in K-12 Escherichia
RT   coli.";
RL   J. Bacteriol. 192:3699-3712(2010).
CC   -!- FUNCTION: Represses EHEC virulence expression. Down-regulates
CC       expression of LEE (locus of enterocyte effacement) and iraD genes, and
CC       alters AE (attaching and effacing) lesion formation. May regulate
CC       transcription through interactions with another HTH DNA-binding
CC       protein. {ECO:0000269|PubMed:20494990}.
CC   -!- INDUCTION: Transcription decreases during mid-log phase and is maximal
CC       during stationary phase. {ECO:0000269|PubMed:20494990}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Exists in some isolates as a HTH-truncated isoform. This short
CC       isoform is still able to regulate gene expression. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; AAG59510.1; -; Genomic_DNA.
DR   PIR; B86131; B86131.
DR   AlphaFoldDB; Q8X487; -.
DR   SMR; Q8X487; -.
DR   STRING; 155864.EDL933_5665; -.
DR   EnsemblBacteria; AAG59510; AAG59510; Z5926.
DR   KEGG; ece:Z5926; -.
DR   PATRIC; fig|83334.175.peg.51; -.
DR   eggNOG; COG0583; Bacteria.
DR   Proteomes; UP000002519; Chromosome.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   Pfam; PF03466; LysR_substrate; 1.
PE   1: Evidence at protein level;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..242
FT                   /note="HTH domain-truncated transcriptional regulator QseD"
FT                   /id="PRO_0000403785"
SQ   SEQUENCE   242 AA;  27718 MW;  942D79E0CF5B2B12 CRC64;
     MTPLQLSEQG KIFHSQIRHL LQQLESNLAE LRGGSDYAQR KIKIAAAHSL SLGLLPSIIS
     QMPPLFTWAI EAIDVDEAVD KLREGQSDCI FSFHDEDLLE APFDHIRLFE SQLFPVCASD
     EHGEALFDLV QPHFPLLNYS RNSYMGRLIN RTLTRHSELS FSTFFVSSMS ELLKQVALDG
     CGIAWLPEYA IQQEIRSGQL VVLNRDELVI PIQAYAYRMN TRMNPVAERF WRELRELEIV
     LS