ID   QSEG_ECO57              Reviewed;         237 AA.
AC   P0AD45; P37328; P76997;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Quorum-sensing regulator protein G;
DE   Flags: Precursor;
GN   Name=qseG; Synonyms=yfhG; OrderedLocusNames=Z3831, ECs3421;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   FUNCTION IN VIRULENCE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND GENE
RP   NAME.
RC   STRAIN=O157:H7 / 86-24 / EHEC;
RX   PubMed=19289831; DOI=10.1073/pnas.0811409106;
RA   Reading N.C., Rasko D.A., Torres A.G., Sperandio V.;
RT   "The two-component system QseEF and the membrane protein QseG link
RT   adrenergic and stress sensing to bacterial pathogenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5889-5894(2009).
RN   [4]
RP   FUNCTION IN REGULATION.
RC   STRAIN=O157:H7 / 86-24 / EHEC;
RX   PubMed=20056703; DOI=10.1099/mic.0.033027-0;
RA   Reading N.C., Rasko D., Torres A.G., Sperandio V.;
RT   "A transcriptome study of the QseEF two-component system and the QseG
RT   membrane protein in enterohaemorrhagic Escherichia coli O157:H7.";
RL   Microbiology 156:1167-1175(2010).
CC   -!- FUNCTION: Involved in the regulation of virulence and metabolism in
CC       EHEC. Required for pedestal formation in host epithelial cells during
CC       infection. Necessary for translocation of effector molecules into host
CC       epithelial cells, but is not involved in structural assembly of the
CC       type III secretion system (TTSS). {ECO:0000269|PubMed:19289831,
CC       ECO:0000269|PubMed:20056703}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:19289831}; Lipid-anchor
CC       {ECO:0000305|PubMed:19289831}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are unable to form pedestals.
CC       {ECO:0000269|PubMed:19289831}.
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DR   EMBL; AE005174; AAG57669.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36844.1; -; Genomic_DNA.
DR   PIR; E91056; E91056.
DR   RefSeq; NP_311448.1; NC_002695.1.
DR   RefSeq; WP_001215861.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AD45; -.
DR   SMR; P0AD45; -.
DR   STRING; 155864.EDL933_3720; -.
DR   PRIDE; P0AD45; -.
DR   EnsemblBacteria; AAG57669; AAG57669; Z3831.
DR   EnsemblBacteria; BAB36844; BAB36844; ECs_3421.
DR   GeneID; 58390601; -.
DR   GeneID; 914899; -.
DR   KEGG; ece:Z3831; -.
DR   KEGG; ecs:ECs_3421; -.
DR   PATRIC; fig|386585.9.peg.3575; -.
DR   eggNOG; COG3170; Bacteria.
DR   HOGENOM; CLU_068067_1_0_6; -.
DR   OMA; SLYWLRA; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025262; QseG.
DR   Pfam; PF13942; Lipoprotein_20; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..237
FT                   /note="Quorum-sensing regulator protein G"
FT                   /id="PRO_0000169250"
FT   REGION          201..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..237
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   237 AA;  27348 MW;  594D0C495759098D CRC64;
     MRHIFQRLLP RRLWLAGLPC LALLGCVQNH NKPAIDTPAE EKIPVYQLAD YLSTECSDIW
     ALQGKSTETN PLYWLRAMDC ADRLMPAQSR QQARQYDDGS WQNTFKQGIL LADAKITPYE
     RRQLVARIEA LSTEIPAQVR PLYQLWRDGQ ALQLQLAEER QRYSKLQQSS DSELDTLRQQ
     HHVLQQQLEL TTRKLENLTD IERQLSTRKP AGNFSPDTPH ESEKPAPSTH EVTPDEP