QSPP_HUMAN
ID QSPP_HUMAN Reviewed; 341 AA.
AC Q5T6V5; B2RPI6; Q8N2B1; Q9BT18;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Queuosine salvage protein {ECO:0000303|PubMed:24911101};
GN Name=C9orf64;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 31-38; 136-148 AND 163-172, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Osteosarcoma;
RA Bienvenut W.V., Glen H., Frame M.C.;
RL Submitted (MAR-2008) to UniProtKB.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-341.
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP FUNCTION.
RX PubMed=24911101; DOI=10.1021/cb500278k;
RA Zallot R., Brochier-Armanet C., Gaston K.W., Forouhar F., Limbach P.A.,
RA Hunt J.F., de Crecy-Lagard V.;
RT "Plant, animal, and fungal micronutrient queuosine is salvaged by members
RT of the DUF2419 protein family.";
RL ACS Chem. Biol. 9:1812-1825(2014).
CC -!- FUNCTION: Involved in salvaging queuosine.
CC {ECO:0000269|PubMed:15164053}.
CC -!- INTERACTION:
CC Q5T6V5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-14710764, EBI-16439278;
CC -!- SIMILARITY: Belongs to the queuosine salvage protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03538.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL354733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471089; EAW62673.1; -; Genomic_DNA.
DR EMBL; BC137461; AAI37462.1; -; mRNA.
DR EMBL; BC137462; AAI37463.1; -; mRNA.
DR EMBL; BC004407; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK090882; BAC03538.1; ALT_INIT; mRNA.
DR CCDS; CCDS6666.2; -.
DR RefSeq; NP_001304926.1; NM_001317997.1.
DR RefSeq; NP_115683.3; NM_032307.4.
DR AlphaFoldDB; Q5T6V5; -.
DR BioGRID; 123994; 29.
DR IntAct; Q5T6V5; 7.
DR MINT; Q5T6V5; -.
DR STRING; 9606.ENSP00000365522; -.
DR iPTMnet; Q5T6V5; -.
DR PhosphoSitePlus; Q5T6V5; -.
DR BioMuta; C9orf64; -.
DR DMDM; 73620030; -.
DR EPD; Q5T6V5; -.
DR jPOST; Q5T6V5; -.
DR MassIVE; Q5T6V5; -.
DR MaxQB; Q5T6V5; -.
DR PaxDb; Q5T6V5; -.
DR PeptideAtlas; Q5T6V5; -.
DR PRIDE; Q5T6V5; -.
DR ProteomicsDB; 64614; -.
DR Antibodypedia; 57741; 107 antibodies from 15 providers.
DR DNASU; 84267; -.
DR Ensembl; ENST00000376344.8; ENSP00000365522.3; ENSG00000165118.15.
DR GeneID; 84267; -.
DR KEGG; hsa:84267; -.
DR MANE-Select; ENST00000376344.8; ENSP00000365522.3; NM_032307.5; NP_115683.3.
DR UCSC; uc004anb.4; human.
DR CTD; 84267; -.
DR DisGeNET; 84267; -.
DR GeneCards; C9orf64; -.
DR HGNC; HGNC:28144; C9orf64.
DR HPA; ENSG00000165118; Low tissue specificity.
DR MIM; 611342; gene.
DR neXtProt; NX_Q5T6V5; -.
DR OpenTargets; ENSG00000165118; -.
DR PharmGKB; PA134865965; -.
DR VEuPathDB; HostDB:ENSG00000165118; -.
DR eggNOG; KOG2524; Eukaryota.
DR GeneTree; ENSGT00390000002374; -.
DR HOGENOM; CLU_036001_2_1_1; -.
DR InParanoid; Q5T6V5; -.
DR OMA; LEHIPFH; -.
DR OrthoDB; 1356655at2759; -.
DR PhylomeDB; Q5T6V5; -.
DR TreeFam; TF105811; -.
DR PathwayCommons; Q5T6V5; -.
DR SignaLink; Q5T6V5; -.
DR BioGRID-ORCS; 84267; 9 hits in 1068 CRISPR screens.
DR ChiTaRS; C9orf64; human.
DR GeneWiki; C9orf64; -.
DR GenomeRNAi; 84267; -.
DR Pharos; Q5T6V5; Tdark.
DR PRO; PR:Q5T6V5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T6V5; protein.
DR Bgee; ENSG00000165118; Expressed in buccal mucosa cell and 195 other tissues.
DR ExpressionAtlas; Q5T6V5; baseline and differential.
DR Genevisible; Q5T6V5; HS.
DR GO; GO:0006400; P:tRNA modification; IBA:GO_Central.
DR GO; GO:0101030; P:tRNA-guanine transglycosylation; IBA:GO_Central.
DR InterPro; IPR019438; Q_salvage.
DR PANTHER; PTHR21314; PTHR21314; 1.
DR Pfam; PF10343; Q_salvage; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Reference proteome.
FT CHAIN 1..341
FT /note="Queuosine salvage protein"
FT /id="PRO_0000089700"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CONFLICT 324
FT /note="H -> Y (in Ref. 5; BAC03538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 341 AA; 39029 MW; 50AF5A7D7197D7B2 CRC64;
MDGLLNPRES SKFIAENSRD VFIDSGGVRR VAELLLAKAA GPELRVEGWK ALHELNPRAA
DEAAVNWVFV TDTLNFSFWS EQDEHKCVVR YRGKTYSGYW SLCAAVNRAL DEGIPITSAS
YYATVTLDQV RNILRSDTDV SMPLVEERHR ILNETGKILL EKFGGSFLNC VRESENSAQK
LMHLVVESFP SYRDVTLFEG KRVSFYKRAQ ILVADTWSVL EGKGDGCFKD ISSITMFADY
RLPQVLAHLG ALKYSDDLLK KLLKGEMLSY GDRQEVEIRG CSLWCVELIR DCLLELIEQK
GEKPNGEINS ILLDYYLWDY AHDHREDMKG IPFHRIRCIY Y