QTC_DROME
ID QTC_DROME Reviewed; 721 AA.
AC Q9VMU5; C8VV94; C9QPB9; E6PBY5; M9MRI9; Q8I0H9; Q95TG9; R4TUN8; R9TC66;
AC X2J8M5; X2J9D4;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Protein quick-to-court {ECO:0000303|PubMed:10747058};
GN Name=qtc {ECO:0000303|PubMed:10747058, ECO:0000312|FlyBase:FBgn0028572};
GN ORFNames=CG14039 {ECO:0000312|FlyBase:FBgn0028572};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL14006.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL14006.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL14006.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000312|EMBL:ACW83548.1, ECO:0000312|EMBL:ACX54885.1, ECO:0000312|EMBL:ACX61590.1, ECO:0000312|EMBL:ADV19046.1, ECO:0000312|EMBL:AGM20425.1, ECO:0000312|EMBL:AGN28833.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B; H; M AND N).
RC STRAIN=Berkeley {ECO:0000312|EMBL:ACW83548.1, ECO:0000312|EMBL:ACX54885.1,
RC ECO:0000312|EMBL:ACX61590.1, ECO:0000312|EMBL:ADV19046.1,
RC ECO:0000312|EMBL:AGM20425.1, ECO:0000312|EMBL:AGN28833.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:ACX54885.1},
RC Head {ECO:0000312|EMBL:ACX61590.1}, and
RC Testis {ECO:0000312|EMBL:ACW83548.1, ECO:0000312|EMBL:ADV19046.1};
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=10747058; DOI=10.1093/genetics/154.4.1627;
RA Gaines P., Tompkins L., Woodard C.T., Carlson J.R.;
RT "quick-to-court, a Drosophila mutant with elevated levels of sexual
RT behavior, is defective in a predicted coiled-coil protein.";
RL Genetics 154:1627-1637(2000).
RN [6] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22292044; DOI=10.1371/journal.pone.0030799;
RA Houot B., Fraichard S., Greenspan R.J., Ferveur J.F.;
RT "Genes involved in sex pheromone discrimination in Drosophila melanogaster
RT and their background-dependent effect.";
RL PLoS ONE 7:e30799-e30799(2012).
CC -!- FUNCTION: In adult males, modulates sexual behavior by playing a role
CC in sex discrimination and maintaining normal levels of sexual activity
CC towards both males and females. {ECO:0000269|PubMed:10747058,
CC ECO:0000269|PubMed:22292044}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=A {ECO:0000312|FlyBase:FBgn0028572}; Synonyms=F
CC {ECO:0000312|FlyBase:FBgn0028572};
CC IsoId=Q9VMU5-1; Sequence=Displayed;
CC Name=B {ECO:0000312|FlyBase:FBgn0028572};
CC IsoId=Q9VMU5-2; Sequence=VSP_060838;
CC Name=H {ECO:0000312|FlyBase:FBgn0028572};
CC IsoId=Q9VMU5-3; Sequence=VSP_060838, VSP_060841, VSP_060842;
CC Name=M {ECO:0000312|FlyBase:FBgn0028572};
CC IsoId=Q9VMU5-4; Sequence=VSP_060839, VSP_060840, VSP_060843;
CC Name=N {ECO:0000312|FlyBase:FBgn0028572};
CC IsoId=Q9VMU5-5; Sequence=VSP_060838, VSP_060840, VSP_060843;
CC -!- TISSUE SPECIFICITY: Expressed in the third antennal segment and the
CC maxillary palp, with increased expression near the cuticle of both
CC olfactory organs (PubMed:10747058). Also detected in the second antenna
CC segment (PubMed:10747058). In the brain, expressed in the central
CC nervous system, with high levels of expression in the visual system
CC including the retina and optic lobe, and uniform expression in the
CC cortex (PubMed:10747058). Detected in the thorax and abdomen, with
CC increased expression in the ventral ganglion (PubMed:10747058). In
CC males, detected in the reproductive tract including the ejaculatory
CC bulb and testis (PubMed:10747058). {ECO:0000269|PubMed:10747058}.
CC -!- DEVELOPMENTAL STAGE: Detected in embryos, adult males and females.
CC {ECO:0000269|PubMed:10747058}.
CC -!- DISRUPTION PHENOTYPE: Adult males appear unable to discriminate between
CC males and females when choosing a mate; either because they display
CC increased levels of courtship behavior towards males (when presented
CC with only males) or they display the same levels of courtship towards
CC both males and females (when presented with both sexes)
CC (PubMed:10747058, PubMed:22292044). During male-female courtship, they
CC also begin courting virgin females earlier than wild-type males,
CC suggesting that their increased tendency to court both sexes may also
CC be due to an increase in male sexual activity (PubMed:10747058). No
CC effect on female sexual behavior, and other aspects of male sexual
CC behavior appear unaffected (PubMed:10747058). RNAi-mediated knockdown
CC in neurons of adult males abolishes their ability to discriminate
CC between male and female during courtship (PubMed:22292044). RNAi-
CC mediated knockdown in the mushroom bodies of adult males, results in a
CC slight, but not significant, decrease in their ability to discriminate
CC between males and females (PubMed:22292044). Howver, RNAi-mediated
CC knockdown in various chemosensory peripheral neurons have no effect on
CC male sex discrimination (PubMed:22292044).
CC {ECO:0000269|PubMed:10747058, ECO:0000269|PubMed:22292044}.
CC -!- MISCELLANEOUS: The name 'quick-to-court' derives from mutant males
CC being quick to initiate courtship of both females and males.
CC {ECO:0000303|PubMed:10747058}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACW83548.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=ADV19046.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGM20425.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AGN28833.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF52216.2; -; Genomic_DNA.
DR EMBL; AE014134; AAN10527.1; -; Genomic_DNA.
DR EMBL; AE014134; AAX52654.1; -; Genomic_DNA.
DR EMBL; AE014134; ADV36940.1; -; Genomic_DNA.
DR EMBL; AE014134; AHN54126.1; -; Genomic_DNA.
DR EMBL; AE014134; AHN54127.1; -; Genomic_DNA.
DR EMBL; AY058777; AAL14006.1; -; mRNA.
DR EMBL; BT099840; ACW83548.1; ALT_INIT; mRNA.
DR EMBL; BT100001; ACX54885.1; -; mRNA.
DR EMBL; BT100049; ACX61590.1; -; mRNA.
DR EMBL; BT125905; ADV19046.1; ALT_INIT; mRNA.
DR EMBL; BT150108; AGM20425.1; ALT_INIT; mRNA.
DR EMBL; BT150112; AGN28833.1; ALT_INIT; mRNA.
DR RefSeq; NP_001014469.1; NM_001014469.2. [Q9VMU5-1]
DR RefSeq; NP_001188690.1; NM_001201761.2. [Q9VMU5-3]
DR RefSeq; NP_001285611.1; NM_001298682.1. [Q9VMU5-4]
DR RefSeq; NP_001285612.1; NM_001298683.1. [Q9VMU5-5]
DR RefSeq; NP_523480.2; NM_078756.4. [Q9VMU5-1]
DR RefSeq; NP_723057.1; NM_164625.2. [Q9VMU5-2]
DR AlphaFoldDB; Q9VMU5; -.
DR SMR; Q9VMU5; -.
DR IntAct; Q9VMU5; 1.
DR STRING; 7227.FBpp0078651; -.
DR PaxDb; Q9VMU5; -.
DR DNASU; 33739; -.
DR EnsemblMetazoa; FBtr0079012; FBpp0078651; FBgn0028572. [Q9VMU5-1]
DR EnsemblMetazoa; FBtr0079013; FBpp0078652; FBgn0028572. [Q9VMU5-2]
DR EnsemblMetazoa; FBtr0100260; FBpp0099649; FBgn0028572. [Q9VMU5-1]
DR EnsemblMetazoa; FBtr0302569; FBpp0291725; FBgn0028572. [Q9VMU5-3]
DR EnsemblMetazoa; FBtr0339791; FBpp0308838; FBgn0028572. [Q9VMU5-4]
DR EnsemblMetazoa; FBtr0339792; FBpp0308839; FBgn0028572. [Q9VMU5-5]
DR GeneID; 33739; -.
DR KEGG; dme:Dmel_CG14039; -.
DR UCSC; CG14039-RA; d. melanogaster. [Q9VMU5-1]
DR UCSC; CG14039-RB; d. melanogaster.
DR CTD; 33739; -.
DR FlyBase; FBgn0028572; qtc.
DR VEuPathDB; VectorBase:FBgn0028572; -.
DR eggNOG; ENOG502RVFC; Eukaryota.
DR HOGENOM; CLU_013488_0_0_1; -.
DR InParanoid; Q9VMU5; -.
DR OrthoDB; 544643at2759; -.
DR PhylomeDB; Q9VMU5; -.
DR BioGRID-ORCS; 33739; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33739; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0028572; Expressed in second segment of antenna (Drosophila) and 56 other tissues.
DR ExpressionAtlas; Q9VMU5; baseline and differential.
DR GO; GO:0007619; P:courtship behavior; TAS:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0048047; P:mating behavior, sex discrimination; IDA:FlyBase.
DR InterPro; IPR000237; GRIP_dom.
DR Pfam; PF01465; GRIP; 1.
DR PROSITE; PS50913; GRIP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Behavior; Coiled coil; Reference proteome.
FT CHAIN 1..721
FT /note="Protein quick-to-court"
FT /id="PRO_0000451730"
FT DOMAIN 668..716
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 511..569
FT /evidence="ECO:0000255"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..156
FT /note="MMTSLQLETSLPAVEEQVQREKDNDSAEDSHTASTTPTRIPHPAVARFRRSA
FT SLRLRGNPAELGLRAEHCPAGGGGFSSRAKLTAIPSSLETRSHPVHLRRNRSWCNLGHK
FT TEQEPEVEASTEALCNAAQCLSLDKEALAPKVGNSSMANGKPRNL -> M (in
FT isoform B, isoform H and isoform N)"
FT /id="VSP_060838"
FT VAR_SEQ 1..156
FT /note="MMTSLQLETSLPAVEEQVQREKDNDSAEDSHTASTTPTRIPHPAVARFRRSA
FT SLRLRGNPAELGLRAEHCPAGGGGFSSRAKLTAIPSSLETRSHPVHLRRNRSWCNLGHK
FT TEQEPEVEASTEALCNAAQCLSLDKEALAPKVGNSSMANGKPRNL -> MASVYLRILK
FT FLVKCSKRVFKKANKKDALASQT (in isoform M)"
FT /id="VSP_060839"
FT VAR_SEQ 623..653
FT /note="Missing (in isoform M and isoform N)"
FT /id="VSP_060840"
FT VAR_SEQ 623..645
FT /note="ASECRMRECGSNHALLTAKEAIS -> VRFFNIFLILFSVLFCVLHFVAS
FT (in isoform H)"
FT /id="VSP_060841"
FT VAR_SEQ 646..721
FT /note="Missing (in isoform H)"
FT /id="VSP_060842"
FT VAR_SEQ 721
FT /note="K -> KLHAKMSKTMSTILVRAKLHCFQLIGWRH (in isoform M and
FT isoform N)"
FT /id="VSP_060843"
FT CONFLICT 245
FT /note="V -> I (in Ref. 4; ACX54885)"
FT /evidence="ECO:0000305"
FT CONFLICT 462
FT /note="G -> R (in Ref. 4; ACX54885)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 721 AA; 80087 MW; 7B249428C5815997 CRC64;
MMTSLQLETS LPAVEEQVQR EKDNDSAEDS HTASTTPTRI PHPAVARFRR SASLRLRGNP
AELGLRAEHC PAGGGGFSSR AKLTAIPSSL ETRSHPVHLR RNRSWCNLGH KTEQEPEVEA
STEALCNAAQ CLSLDKEALA PKVGNSSMAN GKPRNLSLQL NGGSDISSSG TSSSSSNNKE
SSPRTTRTPR TPQTPQTPQT PASGVAASVA ETPHSCIRQG NCVKANQVKL STLHESKISP
RTPPVTPDSP STYLDDDIDS MYSFATTTSG RSTMSCEHPY VARNGTTFSG RKMKYVVHCS
NYAGQVGPDY LTPTQRAQRQ IRRLKELLCI ARQDLEQKDT ELLRLTREVV ELRLFKASLS
SPEERSASSD AVTVREAELK TSQDVSPIVD MVDEGNAKGS PRHLSRQQQQ QANHSLQAMQ
MSAEMQSSYA DSGHFEDLTM SSVHSKDSQT QSEACGTATP DGEADVGCGA GGDSASNLEN
YELQRQELIS MYEHRIEELI RSQDSATSDL KRSHNDKVEA LLQKLAECNT RYSDMVPDYE
QAKQRIRELE KQLEDLQRKL IEHEEKQNKM YLHMYQQGQE AERISRADQA LDLAQRQPES
KVSINELLHQ LQSTQDELEN IRASECRMRE CGSNHALLTA KEAISLWVLG ARKTIYRRLL
EAQKNRTHVD PEVTLQFLKS AIFYFLTDKE NSQGHLQAIE SILEFTDAEK QKISAANRTP
K
