ID   AAEB_ENTCC              Reviewed;         655 AA.
AC   D5CDA0;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE            Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN   Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545}; OrderedLocusNames=ECL_04623;
OS   Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC
OS   13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=716541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=20207761; DOI=10.1128/jb.00067-10;
RA   Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.;
RT   "Complete genome sequence of Enterobacter cloacae subsp. cloacae type
RT   strain ATCC 13047.";
RL   J. Bacteriol. 192:2463-2464(2010).
CC   -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC       relief valve, allowing to eliminate certain compounds when they
CC       accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR   EMBL; CP001918; ADF64151.1; -; Genomic_DNA.
DR   RefSeq; WP_013098977.1; NC_014121.1.
DR   RefSeq; YP_003615100.1; NC_014121.1.
DR   AlphaFoldDB; D5CDA0; -.
DR   SMR; D5CDA0; -.
DR   STRING; 716541.ECL_04623; -.
DR   PRIDE; D5CDA0; -.
DR   EnsemblBacteria; ADF64151; ADF64151; ECL_04623.
DR   KEGG; enc:ECL_04623; -.
DR   PATRIC; fig|716541.4.peg.4771; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_027647_0_0_6; -.
DR   OMA; MITQACE; -.
DR   Proteomes; UP000002363; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR   HAMAP; MF_01545; AaeB; 1.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR   PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..655
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT                   /id="PRO_0000414002"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
SQ   SEQUENCE   655 AA;  73290 MW;  1E01172612149599 CRC64;
     MGIFTIASQH IRFAVKLASA IVLALFVGFH FQLETPRWAV LTAAIVAAGP AFAAGGEPYS
     GAIRYRGMLR IIGTFIGCIA ALTIIILMIR TPLLMVLVCC IWAGFCTWLS SLVKVENSYA
     WGLAGYTALI IVITIQTEPL LAPQFAVERC SEIVIGIVCA IVADLLFSPR SIKQEVDREL
     DALIVSQYQL MQLCIKHGDS EEVDKAWSGL VRRTQALEGM RSNLNMESSR WARANRRLKA
     INTVSLTLIT QACETYLIQN TRPESVTDTF RELFAEPVET VQDVHKQLKR MRRVIAWTGE
     RDTPVTIYTW VGAATRYLLL KRGVIGNTKI SAAEEEVLQG EVVIKAESAE RHHAMVNFWR
     TTLACMLGTL FWLWTGWTSG SGAMVMIAVV TALAMRLPNP RMVAIDFLYG TIAALPLGAL
     YFLVILPSTQ QSMLLLCISL AVMAFFIGIE VQKRRLGSLG ALASTINILV LDNPMTFHFS
     QFLDSALGQL VGCFLAMMVI LLVRDNSQAR TGRVLLNQFV SAAVSSMTTN TARRKENHLP
     ALYQQLFLLL NKFPGDIARF RLALTMIIAH QRLRNAPVPI NDDLSAFHRQ LRRTADHVLS
     ASSDDKRRRY FKQLLEELDV YQEKLRVWEA PPQVTEPVAR LVFMLHRYQN VLTDN