ID   AAEB_PECAS              Reviewed;         662 AA.
AC   Q6DAH4;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE            Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN   Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545}; OrderedLocusNames=ECA0279;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC       relief valve, allowing to eliminate certain compounds when they
CC       accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR   EMBL; BX950851; CAG73199.1; -; Genomic_DNA.
DR   RefSeq; WP_011091913.1; NC_004547.2.
DR   AlphaFoldDB; Q6DAH4; -.
DR   SMR; Q6DAH4; -.
DR   STRING; 218491.ECA0279; -.
DR   EnsemblBacteria; CAG73199; CAG73199; ECA0279.
DR   KEGG; eca:ECA0279; -.
DR   PATRIC; fig|218491.5.peg.281; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_027647_0_0_6; -.
DR   OMA; MITQACE; -.
DR   OrthoDB; 1320135at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR   HAMAP; MF_01545; AaeB; 1.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR   PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..662
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT                   /id="PRO_0000210080"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
SQ   SEQUENCE   662 AA;  73089 MW;  3F71AD8A195EB233 CRC64;
     MKTSSLTGSL FFTTPKFARL RFAFKLSFAI VLSLFLGFHL QLETPRWSVL TAAIVAAGPA
     FAAGGEPFSG AIRHRGMLRI IGTFIGCIGA LVIIIATVRA PVVMLMLCCI WAGLCTWVSS
     LVKVENAYIF GLAGYTALII IVSTQGTPLL TPQFAVERCS EIVLGIVCAI LADLLFSPRS
     IKQDVDRSIG ELLVDQYRLL QLSMSGTEKE AIDAAWHALV RKTTALSGMR SSLMLESSRW
     QNSNRRLTSL HTQSLMMITQ ACETYLILQD VPTPVKSSLK MVLDQPVESL RDVHCRVKAL
     RHLIAADSRD VPPTLIDWVG AATRYLLLAK GVQANGRLNT IEADVLNSDV EIKAPSAETH
     HAMINGLRTG VATALGCLFW LSTGWTSGSV CMVMIAVVTS LAMRLPNPQM MAKDFLFGTI
     YALPLGALMF MFIMPSTQQS MLLLCLSLGG MAFFLGLEVQ KRRLGSLGAL ASTINILVLD
     NPMTFNVSQF LDSAIGQIIG CFLALMVIML IRDNTKAHTG RTLLNRFVYG AVSALTTNRA
     RRKENHLPAL YQQLFLLLNR FPDDIAKYRL ALWLIIMHQR LRTLDIPQNA ALSAFHRQIR
     ATAEQVISAR RDATRSRYFA QLLDELERYQ QMLTEQQLPP SVTAPVGRLT GILRDYQHAL
     SN