ID   QUTA_EMENI              Reviewed;         825 AA.
AC   P10563; C8VTB3; Q5BE96;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Quinic acid utilization activator;
GN   Name=qutA; ORFNames=AN1134;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3313276; DOI=10.1093/nar/15.19.7991;
RA   Beri R.K., Whittington H., Roberts C.F., Hawkins A.R.;
RT   "Isolation and characterization of the positively acting regulatory gene
RT   QUTA from Aspergillus nidulans.";
RL   Nucleic Acids Res. 15:7991-8001(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Transcription activation of genes for enzymes and proteins of
CC       quinate metabolism by binding to a 16 base-pair sequence (consensus 5'-
CC       GGATAANNNNTTATCC-3') in front of each qut gene.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X06252; CAA29594.1; -; Genomic_DNA.
DR   EMBL; AACD01000016; EAA66252.1; -; Genomic_DNA.
DR   EMBL; BN001308; CBF88076.1; -; Genomic_DNA.
DR   PIR; A26983; A26983.
DR   RefSeq; XP_658738.1; XM_653646.1.
DR   AlphaFoldDB; P10563; -.
DR   SMR; P10563; -.
DR   STRING; 162425.CADANIAP00001495; -.
DR   PRIDE; P10563; -.
DR   EnsemblFungi; CBF88076; CBF88076; ANIA_01134.
DR   EnsemblFungi; EAA66252; EAA66252; AN1134.2.
DR   GeneID; 2876901; -.
DR   KEGG; ani:AN1134.2; -.
DR   VEuPathDB; FungiDB:AN1134; -.
DR   eggNOG; ENOG502S3FG; Eukaryota.
DR   HOGENOM; CLU_007607_1_1_1; -.
DR   InParanoid; P10563; -.
DR   OMA; QPEFMQN; -.
DR   OrthoDB; 263891at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:AspGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:AspGD.
DR   GO; GO:0019631; P:quinate catabolic process; IMP:AspGD.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Quinate metabolism;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..825
FT                   /note="Quinic acid utilization activator"
FT                   /id="PRO_0000114970"
FT   DNA_BIND        49..76
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          658..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..675
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        444
FT                   /note="L -> V (in Ref. 1; CAA29594)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        631
FT                   /note="A -> P (in Ref. 1; CAA29594)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        796
FT                   /note="E -> Q (in Ref. 1; CAA29594)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   825 AA;  90398 MW;  D94C11571C3C3416 CRC64;
     MSSDTRQTSG GNARSKRRLT DAVDEDGRPT ATAEDPTSNP KRQRVSRACD SCRSKKDKCD
     GAQPICSTCA SLSRPCTYRA NPKKRGLPTG YIRTLELLWG LVFNKIQGSE EVVRTLLRAA
     NIPSHLATMG KESEGSDTLL SSWKNSIVLK EIERLLTFLE QPEGDQERSA RGEIDSPADA
     EESSVLSPET LEWQLPDSIA VASQSPLASG PSPVRLPRPS TTRLVRDSGT QTIPLGEIED
     LTTNGSSHDR PVIASNSARE EHRLPPNPWP LLDIYFSYTQ CWFPILEKHD ILRTAFRQGD
     DDQYNSPSAA GDNAALWAVL ALASIQQTSI STTRQLSDLP EDRPDPDQLY AKARSLIPTE
     SGTYQLGHIQ ALLILSLIKL GQQDCAAAWM LVGQAVRSAQ SLGLNDPSDA TGVEKTAGRS
     KHVFLGCFVL ETLVAAKLGL LPSLRKTDLT KVGLINEDGL EEWHPWEDQT GLRPIESSRS
     FQRGPLHALS TFNRLLSLMC ILNELCCVRQ TPANSMSYLG TLERQLQLWV SALPTSYRID
     LQTVSTKPAS PHIFGLEMMY EAVATAISLQ LAVQKNERNG LRRASEGSKR LVSLLQAYME
     TYSLSATCPT FGIALTLGLP LPCMKKTAPW AFEASHGINH KLQSFSAHLA TVWIHNTGSQ
     RRPRHATQQG THPRSPMAIS LPGNNMRLTN LIEESRTGNL STTDSYLSPT WMRTSNDENA
     VLSLPTPASS LNIASGVETN PTSQQITHQH RSSVVGKPNS ALIMSDLTTP FPASGHHYQQ
     TYDDASLHFN SLADIESTSS AQRPRIAPDL DALFDELASL DGTDR