QUTD_ASPFN
ID QUTD_ASPFN Reviewed; 537 AA.
AC B8NIM7;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Probable quinate permease;
DE AltName: Full=Quinate transporter;
GN Name=qutD; ORFNames=AFLA_068140;
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC 167;
RX PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
CC -!- FUNCTION: Integral membrane transporter that imports quinic acid to be
CC catabolized as a carbon source. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC membrane {ECO:0000305}.
CC -!- PTM: Ubiquitinated. Deubiquitinated by creB, probably to control its
CC activity or amount.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; EQ963479; EED49992.1; -; Genomic_DNA.
DR RefSeq; XP_002380373.1; XM_002380332.1.
DR AlphaFoldDB; B8NIM7; -.
DR SMR; B8NIM7; -.
DR STRING; 5059.CADAFLAP00008238; -.
DR EnsemblFungi; EED49992; EED49992; AFLA_068140.
DR VEuPathDB; FungiDB:AFLA_068140; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_12_1; -.
DR OMA; KVQWRFF; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019630; P:quinate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Quinate metabolism; Transmembrane;
KW Transmembrane helix; Transport; Ubl conjugation.
FT CHAIN 1..537
FT /note="Probable quinate permease"
FT /id="PRO_0000395714"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..74
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..130
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..325
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..387
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..537
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 537 AA; 60380 MW; 07AFC66810586F9C CRC64;
MSILSLVEDR PTPKEVYNWK IYLLAAVASC TSCMIGYDSA FIGTTISLQS FKDEFDWDSM
SAAHQDLVSS NIVSLYQAGA FFGAFFAYPI GHFWGRKWGL MVSALIFTLG AGIMLGTNGD
RGFGLLYGGR VLAGLGVGAG SNITPIYISE LSPPAIRGRL VGVYELGWQI GGLVGFWICY
GVDETLPPSH KQWIIPFAVQ LIPSGLLIIG ALFLKESPRW LFLRGRREEA IKNLCWIRQL
PEDHVYMIEE IGAIDQTLEH QRATIGLGFW KPFAAAWTNK KILYRLFLGS MLFFWQNGSG
INAINYYSPT VFKSIGVTGS NTSLFTTGIF GVVKTVVTFI WLLWLIDRVG RRLLLLIGAA
GGSICLWIVG AYIKIARPSE RENKQMDGGG IAAMFFFYLW TVFYTPSWNG TPWVINSEMF
DPNIRSLAQA CAAGSNWLWN FLISRFTPQM FAKMDYGVYF FFASLMILSI IFVFFLIPET
KGIPLESMDR LFETQPIWRA HGTLLKQIRE DEERFRHDLE DSGFVKSTDR QVEVVDA
